Evaluating Efficacy of Mitomycin-C in Dacryocystorhinostomy
Authors/Creators
Description
Objectives: To assess the outcomes of mitomycin-c in dacryocystorhinostomy procedure in preventing post-operative granulations, synechiae, and stenosis.
Methods: The study was conducted at a tertiary care hospital between August 2022 and January 2024, involving 30 patients with epiphora who required Endoscopic Dacryocystorhinostomy. Patients were assigned to two groups alternately. Group I had odd number patients who underwent DCR surgery without mitomycin-C application and Group II had even number patients who underwent DCR surgery with mitomycin-C application.
Results: In our study, in group I, 12 out of 15 cases were successful without mitomycin-C application and in group II, 14 out of 15 cases were successful with mitomycin-C application. The results of endoscopic dacryocystorhinostomy with mitomycin-C were 93.34% whereas endoscopic dacryocystorhinostomy without mitomycin-C was 80% after a minimum follow-up period of 6 months. However, this difference in the results is statistically insignificant.
Conclusion: With all these results, it can be concluded that endoscopic endonasal DCR proves beneficial in patients of nasolacrimal obstruction. The creation of the largest possible ostium minimizes the risk for subsequent stenosis and closure of the lacrimal ostium. Despite no statistically significant results is noted between the two groups, there is a trend towards the better outcome with use of mitomycin-C.