Published December 7, 2025 | Version v1
Working paper Open

PROCEDIMENTOS DE ENFERMAGEM PERANTE PACIENTES APRESENTANDO TOXICIDADES ADVINDAS DA IMUNOTERAPIA CAR-T: UMA REVISÃO SISTEMÁTICA DE SÍNTESE SEM METANÁLISE (SWIM)

Authors/Creators

  • 1. ROR icon Centro Universitário Cesmac

Description

Esse trabalho foi apresentado em formato de Slide no IV CONAEDUS - Congresso Nacional de Educação e Saúde (Edição 2025).

O presente trabalho foi apresentado pelo pesquisador Leandro Maia Leão nos dias 8, 9 e 10 de outubro de 2025 em ambiente online.

Segue o link para acesso do registro na plataforma ZENODO dos Anais do IV CONAEDUS: https://zenodo.org/records/18275830

DOI: 10.5281/zenodo.18275830

PDF: https://editorahumanize.com/wp-content/uploads/2025/12/ANAIS-IV-CONAEDUS.pdf

Após o termino do evento, o trabalho foi publicado na plataforma Padlet, em seção criada pelo congresso sobre Temas Livre Apresentados, onde encontra-se no início da página, segue o link de acesso direto ao site está aqui: https://padlet.com/jtb2000abreu/conaedus-congresso-nacional-de-educa-o-e-sa-de-dcpppm7u5x57y6qd

Segue também o link de acesso direto ao documento em PDF via plataforma Padlet: https://padlet.com/jtb2000abreu/conaedus-congresso-nacional-de-educa-o-e-sa-de-dcpppm7u5x57y6qd/wish/E851Q0rXG7ElWVAb

  • Currículo Lattes (Brazilian Academic Curriculum): http://lattes.cnpq.br/4285524447816279
  • ORCID: https://orcid.org/0000-0002-8393-687X
  • Contato via E-mail: leandro-maia-@hotmail.com

Files

[RESUMO EXPANDIDO] Enfermagem Toxicidade CAR-T.pdf

Files (2.9 MB)

Additional details

Identifiers

DOI
10.5281/zenodo.17845693
ISBN
978-65--5255159-7

Related works

Is supplemented by
Book: 10.5281/zenodo.16993584 (DOI)
Working paper: 10.33448/rsd-v14i9.49533 (DOI)
Working paper: 10.33448/rsd-v14i8.49317 (DOI)

Dates

Available
2025-10-10
Trabalho Apresentado
Available
2025-10-10
Trabalho Disponível em Site do Congresso

Software

Repository URL
https://padlet.com/jtb2000abreu/conaedus-congresso-nacional-de-educa-o-e-sa-de-dcpppm7u5x57y6qd
Programming language
Python
Development Status
Active

References

  • BARDIN, L. Análise de conteúdo. 1. ed. Lisboa: Edições 70, 2016.
  • BROWNE, E. K. et al. Evidence-based recommendations for nurse monitoring and management of immunotherapy-induced cytokine release syndrome: A systematic review from the children's oncology group. Journal of Pediatric Oncology Nursing, v. 38, n. 6, p. 399-409, 2021.
  • BRUDNO, J. N.; KOCHENDERFER, J. N. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood, v. 127, n. 26, p. 3321-3330, 2016.
  • BUITRAGO, J. et al. Adult survivorship: Considerations following CAR T-cell therapy. Clinical Journal of Oncology Nursing, v. 23, n. 2, p. 42-48, 2019.
  • CAMPBELL, Mhairi et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ (Clinical research ed.), v. 368, p. l6890, 2020.
  • CORDEIRO, A. et al. Late effects of CD19-targeted CAR-T cell therapy. Blood, v. 132, n. Supplement 1, p. 223-223, 2018.
  • ELLARD, R. et al. The EBMT immune effector cell nursing guidelines on CAR-T therapy: A framework for patient care and managing common toxicities. Clinical Hematology International, v. 4, n. 3, p. 75-88, 2022.
  • ELMARASI, M. et al. CAR-T cell therapy: Efficacy in management of cancers, adverse effects, dose-limiting toxicities and long-term follow up. International Immunopharmacology, v. 135, p. 112312, 2024.
  • ERDAL, S. et al. Evaluation of toxicity associated with CAR-T cell therapy and nursing interventions. Bezmialem Science, v. 12, n. 4, p. 470-478, 2024.
  • ERIKSEN, M. B.; FRANDSEN, T. F. The impact of patient, intervention, comparison, outcome (PICO) as a search strategy tool on literature search quality: a systematic review. Journal of the Medical Library Association, v. 106, n. 4, p. 420-431, 2018.
  • FITZGERALD, J. C. et al. Cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukemia. Critical Care Medicine, v. 45, n. 2, p. e124-e131, 2017.
  • FREY, N.; PORTER, D. Cytokine release syndrome with chimeric antigen receptor T cell therapy. Biology of Blood and Marrow Transplantation, v. 25, n. 4, p. e123-e127, 2019.
  • GUPTA, A. et al. CAR T-cell therapy in cancer: Integrating nursing perspectives for enhanced patient care. Asia-Pacific Journal of Oncology Nursing, v. 11, n. 10, p. 100579, 2024.
  • GUST, J.; TARASEVICIUTE, A.; TURTLE, C. J. Neurotoxicity associated with CD19-targeted CAR-T cell therapies. CNS Drugs, v. 32, n. 12, p. 1091-1101, 2018.
  • HILL, J. A.; SEO, S. K. How I prevent infections in patients receiving CD19-targeted chimeric antigen receptor T cells for B-cell malignancies. Blood, v. 136, n. 8, p. 925-935, 2020.
  • KAMPOURI, E. et al. Managing hypogammaglobulinemia in patients treated with CAR-T-cell therapy: key points for clinicians. Expert Review of Hematology, v. 15, n. 4, p. 305-320, 2022.
  • KISIELEWSKI, D.; NAEGELE, M. Advanced practice nursing and CAR-T cell therapy: Opportunities, challenges and future directions. Seminars in Oncology Nursing, v. 40, n. 3, p. 151628, 2024.
  • KRÖGER, N. et al. (Org.). The EBMT/EHA CAR-T cell handbook. Springer Nature, 2022.
  • LEÃO, L. M. O fármaco vivo a saga da imunoterapia car e a revolução da medicina programável. Amazon Direct Publishing, 2025.
  • LEÃO, L. M. et al. Imunoterapia por Receptores de Antígenos Quiméricos (CARs) para células Assassinas Naturais (NK), abordagens terapêuticas e perspectivas futuras na área oncológica: uma revisão sistemática de Síntese Sem Metanálise (SWIM). Research, Society and Development, v. 14, n. 8, p. e0514849317, 2025a.
  • LEÃO, L. M. et al. Imunoterapia por receptores de antígenos quiméricos no tratamento oncológico: uma revisão integrativa. Revista FT, 2025b.
  • LEÃO, L. M. et al. Fatores de risco para desenvolvimento de síndromes neurotóxicas por uso de células CAR-T: Uma revisão integrativa. Research, Society and Development, v. 14, n. 6, p. e6514649076, 2025c.
  • LEE, D. W. et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood, v. 124, n. 2, p. 188-195, 2014.
  • LEE, D. W. et al. ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells. Biology of Blood and Marrow Transplantation, v. 25, n. 4, p. 625-638, 2019.
  • MAHADEO, K. M. et al. Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. Nature Reviews Clinical Oncology, v. 16, n. 1, p. 45-63, 2019.
  • MONTORO-LORITE, M. et al. Nursing care for chimeric antigen receptor T cell therapy survivors: A literature review. Asia-Pacific Journal of Oncology Nursing, v. 11, n. 6, p. 100495, 2024.
  • MORRIS, E. C. et al. Cytokine release syndrome and associated neurotoxicity in cancer immunotherapy. Nature Reviews Immunology, v. 22, n. 2, p. 85-96, 2021.
  • NEELAPU, S. S. et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. The New England Journal of Medicine, v. 377, n. 26, p. 2531-2544, 2017.
  • OUZZANI, M. et al. Rayyan a web and mobile app for systematic reviews. Systematic Reviews, v. 5, n. 1, p. 210, 2016.
  • PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, v. 372, n71, 2021.
  • PEREIRA, A. S. et al. Metodologia da pesquisa científica. Santa Maria: UAB/NTE/UFSM, 2018.
  • PICANÇO-CASTRO, V. et al. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VIII: CAR-T cells: preclinical development Safety and efficacy evaluation. Hematology, Transfusion and Cell Therapy, v. 43, suppl. 2, p. S54-S63, 2021.
  • RANKIN, A. W. et al. Evolving strategies for addressing CAR T-cell toxicities. Cancer Metastasis Reviews, v. 44, n. 1, p. 17, 2024.
  • ROTHER, E. T. Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem, v. 20, n. 2, p. v-vi, 2007.
  • SANTOMASSO, B. D. et al. Management of immune-related adverse events in patients treated with chimeric antigen receptor T-cell therapy: ASCO guideline. Journal of Clinical Oncology, v. 39, n. 35, p. 3978-3992, 2021.
  • SCHUSTER, S. J. et al. Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma. The New England Journal of Medicine, v. 380, n. 1, p. 45-56, 2019.
  • SNYDER, H. Literature review as a research methodology: An overview and guidelines. Journal of Business Research, v. 104, p. 333-339, 2019.
  • STEWART, A. G.; HENDEN, A. S. Infectious complications of CAR T-cell therapy: a clinical update. Therapeutic Advances in Infectious Disease, v. 8, 2021.
  • YAKOUB-AGHA, I. et al. Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE). Haematologica, v. 105, n. 2, p. 297-316, 2020.