THE PHARMACEUTICAL APPLICATION IN HERBAL NANOPARTICLES
Authors/Creators
- 1. Author B. pharm Final Year, FabtechCollege of Pharmacy.
- 2. Co-author Assistant Professor, Fabtech College of Pharmacy.
- 3. Co-author Principal, Fabtech College of Pharmacy.
Description
Herbal medicines have long been central to ancient healing systems such as Ayurvedic medicine, the Siddha therapeutic tradition, and the heritage healthcare system of China, offering therapeutic benefits with comparatively fewer side effects. Advances in nanotechnology have provided innovative strategies to overcome these challenges by incorporating herbal bioactives into nanometric therapeutic delivery platforms, including polymer-based nanocarriers and solid-lipid nanostructures,metallic and ceramic nanoparticles, and green-synthesized nanocarriers. These systems enhance solubility, protect unstable phytoconstituents, prolong circulation time, and enable targeted and controlled release. Various preparation techniques—such as green synthesis, coacervation, salting-out, solvent diffusion-emulsification, supercritical fluid processing, and high-pressure homogenization—offer versatile approaches for developing efficient nanocarriers. Characterization tools such as SEM, TEM, DLS, AFM, BET analysis, and particle-size analyzers ensure accurate evaluation of nanoparticle properties critical
Files
7 WJPSR 1859.pdf
Files
(444.1 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:d2d0c76285838f41c424614856ac1bd3
|
444.1 kB | Preview Download |
Additional details
References
- 1. Kesarwani, K., & Gupta, R., Bioavailability enhancers of herbal origin: An overview. Asian Journal of Tropical Biomedicine, 2013; 3(4): 253–266.
- 2. Goyal, A., Kumar, S., Nagpal, M., Singh, I., & Arora, S., Potential of novel drug delivery systems for herbal drugs. Indian Journal of Pharmaceutical Education and Research, 2011; 45: 225–235.
- 3. Thakur, L., Ghodasra, U., Patel, N., & Dabhi, M., Novel approaches for stability improvement in natural medicines. Pharmacognosy Reviews, 2011; 5: 48–54.
- 4. Williamson, E. M., Synergy and other interactions in phytomedicines. In A. Luch (Ed.), Phytomedicine, 2001; 8(5): 401–409.
- 5. Kumar, K., & Rai, A. K., Miraculous therapeutic effects of herbal drugs using novel drug delivery systems. International Research Journal of Pharmacy, 2012; 3: 27–33.
- 6. Sharma, A. T., Mitkare, S. S., & Moon, R. S., Multicomponent pharmaceutical science review and research. Pharmaceutical Science Review and Research, 2011; 6: 185–187.
- 7. Yadav, D., Suri, S., Choudhary, A. A., Sikender, M., Heman, & Beg, M. N., et al., Novel approach, herbal remedies and natural products in pharmaceutical science as nano drug delivery systems. International Journal of PharmTech Research, 2011; 3(3): 3092–3116.
- 8. Ratnam, D. V., Ankola, D. D., Bhardwaj, V., Sahana, D. K., & Kumar, M. N., Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. Journal of Controlled Release, 2006; 113: 189–207.
- 9. Kamboj, V. P., Herbal medicine. Current Science, 2000; 78(1): 35–39.
- 10. Wachtel-Galor, S., & Benzie, I. F., Herbal medicine. In L. Packer (Ed.), [Book/volume title not provided], 2011; p.1. [Publisher not provided].
- 11. Pal, S. K., & Shukla, Y., Herbal medicine: Status and the future. Asian Pacific Journal of Cancer Prevention, 2003; 4(4): 281–288.
- 12. Khan, M. S., & Ahmad, I., Herbal medicine: Current trends and prospects. In New Look to Phytomedicine, 2019; pp. 3–13. [Publisher not provided].
- 13. Emerich, D. F., & Thanos, C. G., Nanotechnology and medicine. Expert Opinion on Biological Therapy, 2003; 3(4): 655–663.
- 14. Poole, C. P., & Owens, F. J., Introduction to nanotechnology. Wiley, 2003.
- 15. Schmid, G. (Ed.)., Nanoparticles: From theory to application. John Wiley & Sons, 2011.
- 16. Wilczewska, A. Z., Niemirowicz, K., Markiewicz, K. H., & Car, H., Nanoparticles as drug delivery systems. Pharmacological Reports, 2012; 64(5): 1020–1023.
- 17. Devi, V. K., Jain, N., & Valli, K. S., Importance of novel drug delivery systems in herbal medicines. Pharmacognosy Reviews, 2010; 4(7): 27.
- 18. Mamilla Alli, V., Nanoparticles for herbal extracts. Asian Journal of Pharmaceutics, 2016; 10(2).
- 19. Verma, H., Prasad, S. B., & Yashwant, S. H., Herbal drug delivery system: A modern era prospective. International Journal of Current Pharmaceutical Review and Research, 2013; 4: 88–101.
- 20. Vollath, D., Nanomaterials: An introduction to synthesis, properties and application. Environmental Engineering and Management Journal, 2008; 7(6): 865–870.
- 21. Lue, J. T., Physical properties of nanomaterials. In Encyclopedia of Nanoscience and Nanotechnology Los Angeles, CA: American Scientific Publishers, 2003; Vol. 8: 1–17.
- 22. Van Vlerken, L. E., & Amiji, M. M., Multi-functional polymeric nanoparticles for tumor-targeted drug delivery. Expert Opinion on Drug Delivery, 2006; 3(2): 205–216.
- 23. Mamillapalli, V., Atmakuri, A. M., & Khantamneni, P., Nanoparticles for herbal extracts. Asian Journal of Pharmaceutics [Page range in the original citation appeared incomplete—please provide the full page range if you want an exact APA page span] , 2010; 10(2): 554.
- 24. Gawai, A. Y., Bakal, R. I., Hatwar, F. R., Nehar, K. N., & Bhujade, P. R., Introduction about global infectious disease and use of nanotechnology. Journal of Drug Delivery and Therapeutics https://doi.org/10.22270/ddtv14.12.6915 (I normalized the DOI to a standard format — if you have the publisher's DOI exactly as printed, send it and I'll insert the original.), 2024; 14(12): 181–190.
- 25. Verma, H., Prasad, S. B., Singh, Y., & Singh, H., Herbal drug delivery system: A modern era prospective. International Journal of Current Pharmaceutical Review and Research, 2013; 4(3): 88–101.
- 26. Liu, M., Dong, J., Yang, Y., Yang, X., & Xu, H., Anti-inflammatory effects of triptolide loaded poly (D, L-lactic acid) nanoparticles on an adjuvant-induced arthritis in rats. Journal of Ethnopharmacology, 2005; 97: 219–225.
- 27. Sahu, A., Bora, U., Kasoju, N., & Goswami, P., Synthesis of novel biodegradable and self-assembling methoxy poly (ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomaterialia, 2008; 4: 1752–1761.
- 28. Zhang, L., & Kosaraju, S. L., Biopolymeric delivery system for controlled release of polyphenolic antioxidants. European Polymer Journal, 2007; 43: 2956–2966.
- 29. Wang, F., Zhou, L., & Gu, F., Characterization of anticancer hypocrellin A encapsulated with silica nanoparticles. Journal of Thermal Analysis and Calorimetry, 2010; 80: 213–218.
- 30. Leonard, K., Ahmmad, B., Okamura, H., & Kurawaki, J., In situ green synthesis of biocompatible ginseng-capped gold nanoparticles with remarkable stability. Colloids and Surfaces B: Biointerfaces, 2011; 82: 391–396.
- 31. Satyavani, K., Ramanathan, T., & Gurudeeban, S., Plant mediated synthesis of biomedical silver nanoparticles by using leaf extract of Citrullus colocynthis. Research Journal of Nanoscience and Nanotechnology, 2011; 1–7.
- 32. Dong, X., Mattingly, C. A., Tseng, M. T., Cho, M. J., Liu, Y., & Adams, V. R., Doxorubicin and paclitaxel-loaded lipid-based nanoparticles to overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP. Cancer Research, 2009; 69: 3918–3926.
- 33. Shi, F., Zhao, J. H., Liu, Y., Wang, Z., Zhang, Y. T., & Feng, N. P., Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil. International Journal of Nanomedicine, 2012; 7: 2033–2043.
- 34. Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodriguez-Torres, M. D. P., Acosta-Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., Habtemariam, S., & Shin, H.-S., Nano based drug delivery systems: Recent developments and future prospects. Environmental Chemistry Letters, 2020; 18: 703–728. https://doi.org/10.1007/s10311-020-01074-x
- 35. Ansari, S. H., et al., Influence of nanotechnology on herbal drugs: A review. Journal of Advanced Pharmaceutical Technology & Research, 2012; 3(3): 142–146.
- 36. Sahni, J. K., et al., Promising role of nanopharmaceuticals in drug delivery. Pharma Times, 2011; 43: 16–18.
- 37. Lachman, L., & Lieberman, H. A. (n.d.). The Theory and Practice of Industrial Pharmacy (3rd ed., p. 420). [Publisher missing].
- 38. Sheehan, D., & Blackwell, W., Physical Biochemistry, 2009; (p. 285). [Publisher missing].
- 39. Back, B. M., et al. (2010, October). [Article title missing]. European Journal of Pharmaceutical Sciences, 9. [Page numbers missing].
- 40. Jung, J., & Perrut, M., et al., Particle design using supercritical fluids: Literature and patent survey. Journal of Supercritical Fluids, 2001; 20: 179–219.
- 41. Pal, S. L., et al., Nanoparticle: An overview of preparation and characterization. Journal of Applied Pharmaceutical Science, 2011; 1(6): 228–234.
- 42. Molpeceres, J., Aberturas, M. R., & Gurman, M., Biodegradable nanoparticles as a delivery system for cyclosporine: Preparation and characterization. Journal of Microencapsulation, 2000; 17(5): 599–614.
- 43. Demais, D. N., Mosqueita, V. C., Vilela, J. M., Andrade, M. S., & Cardoso, V. N., Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of 99m technetium-fluconazole nanocapsules. International Journal of Pharmaceutics, 2008; 349(1–2): 152–160.
- 44. Shi, H. G., Farber, L., Michaels, I. N., Dickey, A., Thompson, K. C., Shelukar, S. D., et al., Characterization of crystalline drug nanoparticles using atomic force microscopy and complementary techniques. Pharmaceutical Research, 2003; 20(3): 479–484.
- 45. Polakovic, M., Gomer, T., Gref, R., & Dellacherie, E., Lidocaine loaded biodegradable nanospheres—II: Modelling of drug release. Journal of Controlled Release, 1999; 60(2–3): 169–177.
- 46. Pungi, Z., Beletsi, A., & Evangelatos, K., PEG-ylated nanoparticles for biological and pharmaceutical applications. Advanced Drug Delivery Reviews, 2003; 24: 403–419.
- 47. Ravishankar B, Shukla VJ. Indian systems of medicine: a brief profile. African Journal of Traditional, Complementary and Alternative Medicines, 2007; 4(3): 319–337.
- 48. Reichard P, Nielsen OS, Bauer S, Hartmann JT, Schoffski P, Christensen TB. Exatecan in pretreated adult patients with advanced soft tissue sarcoma: result of a phase-II study of the EORTC Soft Tissue and Bone Sarcoma Group. European Journal of Cancer, 2007; 43: 1017–1022.
- 49. Roy AM, Baliga MS, Elmets CA, Katiyar SK. Grape seed proanthocyanidins induce apoptosis through p53, Bax, and caspase-3 pathways. Neoplasia, 2005; 7: 24–36.
- 50. Anand P, Kunnumakkara AB, Newman RA. Bioavailability of curcumin: Problems and promises. Molecular Pharmaceutics, 2007; 4(6): 807–818.
- 51. Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A. Polymeric nanoparticles-encapsulated curcumin (nanocurcumin): a novel strategy for human cancer therapy. Journal of Nanobiotechnology, 2007; 5(3): 2–18.
- 52. Nerngchamnong N, Lokkerbol HA, Ingkaninan K. Separation and detection of the antioxidant flavonoids, rutin and quercetin, using HPLC coupled on-line with colorimetric detection of antioxidant activity. Naresuan University Journal, 2004; 12: 25–37.
- 53. Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology, 1995; 33: 1061–1080. Schaab MR, Barney BM, Francis WA. Kinetic and spectroscopic studies on the quercetin 2, 3-dioxygenase from Bacillus subtilis. Biochemistry, 2006; 45: 1009–1016.
- 54. Gupta, D. K., Wani, S. K., Sharma, N. K., & Gupta, M. K., Formulation and evaluation of herbal extract of Allium sativum (garlic) loaded chitosan nanoparticles. Journal of Drug Delivery and Therapeutics, 2019; 9(5): 715–718. https://doi.org/[DOI if available]
- 55. Bais, S. K., & Kazi, S. M., Review on novel herbal drug delivery systems. International Journal of Advanced Research in Science, Communication and Technology (IJARSCT), 2024; 4(2): 7917–7925.* https://www.ijarsct.co.in/Paper7917.pdf
- 56. Pore, A., Bais, S. K., & Galave, R. N., Review on Novel Herbal Drug Delivery System. Research & Reviews: Journal of Pharmaceutics and Nanotechnology, 2023; 11: 011. https://doi.org/10.4172/2347-7857.11.2.011.
- 57. Wang F, zhouL, GUF: Characterization of anticancer hypocrellina encapsulated with silica nanoparticles. Juornal of thermal analysis and calorimetry, 2010; 80: 2013-18.