Published December 5, 2025
| Version v1
Preprint
Restricted
Pathophysiology and Therapeutic Remodeling of Androgenetic Alopecia (Male Pattern Baldness) via Bio-Electric and Hydrodynamic Restoration
Description
Abstract:
Current standard of care for Androgenetic Alopecia (Male Pattern Baldness) focuses on symptomatic suppression, neglecting the underlying hydrodynamic and bio-electric failure. This paper elucidates the specific failure mechanism: Galeal Tension-Induced Follicular Hypoxia. We present a mechanistic derivation of pathology, moving from the cellular level (Current consensus attributes MPB to DHT sensitivity. However, DHT is upregulated in response to mechanical stress. The primary lesion is chronic tension in the Galea Aponeurotica (Scalp Fascia) driven by Cranial muscle contraction. This tension compresses the perifollicular capillaries, creating a hypoxic micro-environment. Hypoxia upregulates HIF-1alpha, which increases TGF-beta1 (Fibrosis) and 5-alpha-reductase (DHT conversion). The hair loss is an ischemic event, not purely hormonal.) to the systemic manifestation. A Triad Therapeutic Protocol is proposed, targeting the Electrolyte Medium, the Vascular Dynamics, and the Neurological Signal to restore homeostatic integrity.
Current standard of care for Androgenetic Alopecia (Male Pattern Baldness) focuses on symptomatic suppression, neglecting the underlying hydrodynamic and bio-electric failure. This paper elucidates the specific failure mechanism: Galeal Tension-Induced Follicular Hypoxia. We present a mechanistic derivation of pathology, moving from the cellular level (Current consensus attributes MPB to DHT sensitivity. However, DHT is upregulated in response to mechanical stress. The primary lesion is chronic tension in the Galea Aponeurotica (Scalp Fascia) driven by Cranial muscle contraction. This tension compresses the perifollicular capillaries, creating a hypoxic micro-environment. Hypoxia upregulates HIF-1alpha, which increases TGF-beta1 (Fibrosis) and 5-alpha-reductase (DHT conversion). The hair loss is an ischemic event, not purely hormonal.) to the systemic manifestation. A Triad Therapeutic Protocol is proposed, targeting the Electrolyte Medium, the Vascular Dynamics, and the Neurological Signal to restore homeostatic integrity.
Files
Restricted
The record is publicly accessible, but files are restricted to users with access.