Published December 4, 2025 | Version v1
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Isoxazole mediated synthesis of 4-(1H)Pyridones: improved preparation of antimalarial candidate GSK932121

Description

In this paper is described a straightforward synthesis of antimalarial clinical candidate GSK932121 through a innovative synthesis that involves reductive opening of a functionalized isoxazole ring to afford the desired 4(1H)pyridone scaffold.

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Identifiers

DOI
10.1039/C6CC05277K

Dates

Available
2025-12-11
journal article