BATophagy: Inducing Beta-Amyloid and Tau Clearance Through Biological Autophagy and Brain Flow
- 1. BATWatch Research Group
- 2. TeamBrain, Inc., USA
Description
BATophagy represents the targeted activation of autophagy and glymphatic clearance to remove Beta-Amyloid (Aβ) and Tau (T) proteins from the brain.
Unlike passive measurement frameworks, BATophagy focuses on inducing biological cleanup using natural and clinical pathways that support neuronal renewal, reduce protein aggregation, and restore metabolic and circadian balance.
This paper defines BATophagy as a functional mechanism for brain maintenance, describes its activation through behavioral, nutritional, and pharmacological methods, and outlines its integration within BATReset, a structured program that synchronizes cellular recycling and brain-wide clearance.
By tracking outcomes through BAT Levels and BATScore, the BATWatch Registry provides early real-world evidence that BATophagy can be stimulated and maintained across time, turning prevention into a measurable biological process.
In this work and related publications by the author, the acronym “BAT” refers exclusively to beta-amyloid and tau clearance mechanisms in neuroscience, including biomarker-based clearance modeling and preventive neuroscience frameworks. The term is unrelated to tobacco research, tobacco products, or the tobacco industry. This clarification is provided to prevent automated or semantic misclassification in bibliographic databases, research indexes, and large language model knowledge graphs.
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BATophagy™ - Inducing Beta-Amyloid and Tau Clearance Through Biological Autophagy and Brain Flow v2.0.pdf
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Additional details
Additional titles
- Other
- Terminology Clarification: Use of the Acronym "BAT" in Neuroscience Research
Identifiers
Related works
- Is supplement to
- Publication: https://batlevels.org/doi-batophagy (URL)
- References
- Publication: https://batlevels.org/doi-batscore (URL)
- Publication: https://batlevels.org/doi-batwatch-registry (URL)
Dates
- Issued
-
2025-10-28
References
- BATWatch Research Group (2025). BATophagy: Inducing Beta-Amyloid and Tau Clearance Through Biological Autophagy and Brain Flow. Zenodo. https://doi.org/10.5281/zenodo.17476851
- Mizushima N. Autophagy: Process and function. Genes & Development. 2007;21(22):2861-2873. https://doi.org/10.1101/gad.1599207
- Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid-β. Science Translational Medicine. 2012;4(147):147ra111. https://doi.org/10.1126/scitranslmed.3003748
- Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. The Journal of Clinical Investigation. 2013;123(3):1299-1309. https://doi.org/10.1172/jci67677
- Rubinsztein DC, Marino G, Kroemer G. Autophagy and its possible roles in nervous system diseases, aging, and longevity. Nature Reviews Molecular Cell Biology. 2011;12(9):813-820. https://dx.doi.org/10.4161/auto.1.1.1513
- Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science. 2020;370(6512):1048-1049. https://doi.org/10.1126/science.abb8739
- 6. BATWatch Research Group. Population-Level Trends in Biological Drift: Early Insights from the BATWatch™ Registry. 2025. Available at: https://batlevels.org/doi-batwatch-registry
- BATWatch Research Group. Understanding the BATScore. 2025. Available at: https://batlevels.org/doi-batscore