Published November 26, 2026
| Version v1
Dataset
Open
Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes
Authors/Creators
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1.
University Hospital Heidelberg
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2.
German Cancer Research Center
Description
Breast cancer brain metastases (BCBM) are a severe condition with high demand for improved personalized treatment, but a comprehensive understanding of BCBM immune-microenvironment heterogeneity and susceptibility to immunotherapy is lacking. Here, we multimodally profile the immune niche in a vast, clinically annotated cohort of BCBM applying tissue cytometry, bulk and single nuclei RNA-sequencing, and spatial transcriptomics, complemented by flow cytometric and functional studies in patient-derived organoids. Here the spatial and snRNAseq data is deposited.
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