NEUROENDOCRINE MODULATION THROUGH NASYA KARMA IN POLYCYSTIC OVARY SYNDROME (PCOS)

Introduction: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder characterized by neuroendocrine dysregulation, particularly in the hypothalamic–pituitary–ovarian (HPO) axis. Traditional Ayurvedic therapy, Nasya Karma, has been proposed to modulate neuroendocrine function via nasal administration of herbal oils. This study explores mechanisms by which Nasya may influence neurohormonal pathways in PCOS. Methods: A narrative review was conducted using classical Ayurvedic texts, recent clinical reports, and modern neuroendocrine research on PCOS. Databases included PubMed, Google Scholar, and Ayurvedic journals focusing on Nasya interventions. Results: Nasya Karma, through intranasal delivery, may act on olfactory and trigeminal neural pathways, influencing the central nervous system and modulating GnRH pulsatility. Herbal oils used in Nasya (e.g., Brahmi, Jatamansi, Shatavari) have adaptogenic, anti-inflammatory, and neuro-regulatory effects. Neuroendocrine studies in PCOS demonstrate elevated GnRH pulse frequency, increased kisspeptin and neurokinin B signaling, and altered neurotransmitters (GABA, glutamate, serotonin). Discussion: Integration of Ayurvedic and neuroendocrine perspectives suggest Nasya may restore neuroendocrine balance in PCOS by modulating upstream regulators of GnRH via KNDy neurons. This may reduce LH hypersecretion and hyperandrogenism. Case reports show potential clinical effects, though controlled trials are limited. Conclusion: Nasya Karma may be a promising non-pharmacological intervention for PCOS targeting neuroendocrine dysfunction. Future studies including randomized controlled trials and neurohormonal biomarker assessments are warranted.