Prediction of allergenic proteins and mapping of IgE epitopes in allergens

In present era use of genetically modified proteins in foods, therapeutics and biopharmaceuticals is increasing with exponential rate. Thus it is important to predict whether a modified protein allergenic or not. In 2003, the Codex Alimentarius Commission (Codex) conveyed a panel of international food safety regulators to review the FAO/ WHO 2001 recommendations and recognized the uncertainties associated with the bioinformatics part of the guidelines. They recommended various tests for examining allergenic behavior of proteins that includes source of gene, sequence similarities with known allergens, stability of protein and IgE bindings. Considering these points in mind a method was developed for predicting allergenic proteins, which is based on various approaches.