Published November 18, 2025 | Version v1
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Comparative gene expression analysis in closely related dermatophytes reveals secondary metabolism as a candidate driver of virulence

Description

The study examines Trichophyton benhamiae var. luteum, an emerging dermatophyte causing epidemic skin infections in Europe. It shows that genes tied to secondary metabolism are strongly upregulated during skin infection compared to related taxa. These metabolites likely enhance virulence by weakening host defenses, pointing to new diagnostic and therapeutic targets.

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Additional details

Funding

European Commission
MYCOBIOMICS - Joining forces to exploit the mycobiota of Asia, Africa and Europe for beneficial metabolites and potential biocontrol agents, using -OMICS techniques 101008129

Dates

Issued
2025-10-09

References

  • Machová L, Kostovčík M, Švec K, Hubka V, Kolařík M, Wennrich A. (2025) Comparative gene expression analysis in closely related dermatophytes reveals secondary metabolism as a candidate driver of virulence. Microbiol Spectr. 13(11):e0138325. doi: 10.1128/spectrum.01383-25. Epub 2025 Oct 9.