LSECtin attenuates hepatic Th17 expansion in a murine model of cirrhosis and signals through the LAG-3 receptor

Martínez-López, Sebastian; Juanola, Oriol; Gómez-Hurtado, Isabel; Ángel-Gomis, Enrique; Boix, Paula; Fernández-Iglesias, Anabel; Gallardo-Cruz, Alex; Cubero, Francisco Javier; Gracia-Sancho, Jordi; Puig-Kröger, Amaya; Caparrós, Esther; Francés, Rubén

doi:10.1016/j.jhepr.2025.101482

Published June 2025 | Version v1

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LSECtin attenuates hepatic Th17 expansion in a murine model of cirrhosis and signals through the LAG-3 receptor

LSECtin downregulation during cirrhosis progression is associated with adaptive T-cell expansion. We analyzed the molecular mechanism for LSECtin modulation of Th17 proliferation in an experimental cirrhosis model.

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European Commission
halt-RONIN - Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH (non-alcoholic steatohepatitis) transition to inform early prevention and treatment strategies 101095679

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JHEP Rep.

License: Creative Commons Attribution 4.0 International

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Created: November 18, 2025
Modified: November 18, 2025

LSECtin attenuates hepatic Th17 expansion in a murine model of cirrhosis and signals through the LAG-3 receptor

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