Cubosomes in the Spotlight: Next-Generation Nanocarriers for Smart Drug Delivery and Beyond

ABSTRACT
Cubosomes are nanostructured, self-assembling liquid crystalline particles that resemble
liposomes but have a distinct cubic phase structure with improved stability and flexibility. Due to
their capacity to effectively encapsulate and deliver a variety of nanoparticles, cubosomes, which
were initially described by Larsson in 1980, have gained considerable attention in
nanotechnology-based drug delivery.Broad variety of chemicals, such as proteins, peptides,
nucleic acids, and chemicals with low molecular weight.Cubosomes facilitate regulated and
targeted medication release because they have a bicontinuous cubic liquid crystalline phase with
internal aqueous channels. Their use has increased because of a variety of preparation
techniques, including top-down and bottom-up methodologies, as well as novel formulation
techniques like surface functionalization and stimulus-responsive systems. Despite difficulties
such as excessive viscosity, stability, drug leakage, manufacturing expenses, and scalability,
cubosomes have a bright future in the pharmaceutical, cosmetic, agricultural, and diagnostic
industries. Ongoing improvements are being made to delivery systems.