The Association between ambient air pollution and resistant hypertensive disorders in pregnancy: a case-control study in Tashkent
Authors/Creators
- 1. Ferghana Medical Insititute of Public Health Department of Epidemiology and Infectious Disease Treatment, Nursing PhD, dotsent. Uzbekistan
- 2. Department of Epidemiology and Infectious Disease Treatment, Nursing assistant, Ferghana Medical Insititute of Public Health Uzbekistan
- 3. Senior Lecturer of the Department of General Hygiene Head teacher, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan
- 4. Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan
- 5. Senior teacher, Department of Department of Medical Chemistry and Biological Sciences, Central Asian Medical University, Uzbekistan
- 6. docent, Health Department of Microbiology, virology and immunalogy, Ferghana Medical Insititute of Public, Uzbekistan
- 7. Department of Therapy, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Republic of Uzbekistan;
- 8. Candidate of Pedagogical Sciences, Associate Professor, Department of Pedagogy and Psychology, Tashkent State Medical University, Tashkent, Republic of Uzbekistan
Description
The present study was carried out to assess the association between ambient air pollution exposure and resistant hypertension disorders development in pregnancy by a case-control study in Tashkent city. The present study included 150 pregnant women with resistant hypertension disorders (cases) and 300 pregnant women without the disorder (controls). The chronic exposure to particulate matter pollutants less than 2.5 microns (PM₂.₅), nitrogen dioxide (NO₂), and ozone (O₃) throughout pregnancy was calculated based on the air quality monitoring station data. The comparison was made using conditional logistic regression and adjusting for the confounding effect of the variables. The findings showed the average exposure to PM₂.₅ and NO₂ in the case group were greater than that in the control group. For a 10 micrograms per cubic meter increase in PM₂.₅ concentration, the adjusted odds ratio for refractory hypertension was 2.01 (95% confidence interval: 1.51-2.68). For an 8.5 ppm increase in NO₂ concentration, the adjusted odds ratio was 1.85 (95% confidence interval: 1.41-2.42). For ozone, there was no significant association. The results from this study demonstrate that maternal exposure to elevated levels of PM₂.₅ and NO₂ air pollutants is associated with an increased incidence of refractory hypertension in pregnancy. These findings underscore the importance of taking air pollution seriously as a modifiable risk factor for this life-threatening pregnancy complication and implementing appropriate policies to improve air quality to promote maternal health.
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References
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