Polypharmacy as a Physical Limit of the Human Body

Polypharmacy—the simultaneous use of multiple medications—is traditionally explained biochemically or pharmacologically. This essay presents a different perspective: polypharmacy is primarily an overload of the physical adaptive capacity of the human body. Vesicles, membranes, and ion gradients function as microsystems with limited stabilization speed. When medications cause changes faster than these microsystems can compensate for, equilibrium collapses—not as a psychological failure, but as a physical limit of life.