Published November 12, 2025
| Version 1.0.0
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Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record
Authors/Creators
- 1. Kapodistrian Academy of Science
- 2. Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic
Description
Open scientific disclosure and LaTeX documentation for the Tri-Modal Antifungal Catheter Lock (TCL) — a non-systemic antifungal catheter lock combining three synergistic mechanisms: (1) echinocandin inhibition of β-glucan synthase, (2) β-1,3-glucanase enzymatic digestion of the extracellular matrix, and (3) gallium(III)/EDTA complex-induced iron substitution disrupting fungal metabolic integrity. Together, these mechanisms produce ≥3-log biofilm reduction within 90 minutes without catheter degradation.
Notes
This record constitutes timestamped prior-art disclosure for open scientific collaboration. Commercial manufacturing or distribution of TCL formulations requires prior written authorization. Contact avalamontes@kapodistrian.edu.gr for licensing inquiries.
Files
Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL-TCLv1.0.zip
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Additional details
Related works
- Is supplement to
- https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL (URL)