Project description

This project will combine MRI structural images, multi-echo resting-state functional images, task-based functional images, and diffusion tensor imaging (DTI) to locate the brain region targets that are most relevant to the target dysfunction. Then, the optimal stimulation parameters will be designed. Finally, combined with specific task training, precise target regulation of online repetitive transcranial magnetic stimulation (online rTMS) will be achieved.

Inclusion criteria:

1. Stroke is diagnosed for the first time through neurological examination, CT or MRI scans.
2. Vital signs are stable, and there is a certain degree of upper limb motor dysfunction.
3. The age ranges from 20 to 80 years old.
4. Cognitive ability is not significantly affected, and the patient is able to cooperate with various examination assessments. The Mini-Mental State Examination (MMSE) score is ≥ 20 points.
5. There are no severe complications (such as pneumonia, heart failure, urinary tract infection or malnutrition).
6. There is no pathological condition that is a contraindication for transcranial magnetic stimulation (TMS) in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures).
7. The patient or the guardian agrees to sign the informed consent form.

Exclusion criteria:

1. Patients with severe heart, lung, liver, kidney diseases or malignant tumors;
2. Those with aphasia, severe cognitive impairment or a history of mental illness;
3. Patients who have had a history of epileptic seizures in the last month or have recently taken anti-epileptic drugs;
4. Those with severe visual or hearing impairments, unable to communicate normally;
5. Individuals with metal implants, pacemakers, skull defects or other conditions that prevent transcranial magnetic stimulation (TMS) from being carried out.

Primary outcome:

Fugl-Meyer Assessment of Upper Extremity,FAM-UE

The way of sharing IPD

Method of obtaining the raw data: If there are reasonable requests, the related raw data to support the research results can be obtained from the corresponding authors or the first authors. Time of making the raw data public: the research raw data will be publicly shared six months after the publication of the research paper.

Dataset and code description

To be uploaded...