Facile radiolabeling of monoclonal antibodies and other proteins with zirconium-89 or gallium-68 for PET imaging using p-isothiocyanatobenzyl-desferrioxamine

Presently, hundreds of monoclonal antibodies (mAbs) and mAb fragments are under clinical development because of their excellent potential for the systemic treatment of cancer and other pathological conditions (1, 2). Positron emission tomography (PET) offers an exciting imaging option to confirm and quantify selective tumor uptake of such targeting molecules (3).