Acquired Savant: Brain‑Immune Reset, Game‑Primed Plasticity, and External Bio‑Topo Cues

Aim. To advance a falsifiable framework for Acquired Savant‑like rapid learning without tissue injury, by leveraging brief brain‑immune reset events (LC‑mediated), game‑primed plasticity (reward‑prediction/BDNF), and closed‑loop timing (pupil/blink) — optionally supported by structured, external bio‑topological cues (Dust‑Betti motifs from a web‑biofilm sensor). Rather than asserting exotic synchronization, we treat the external sensor as a pattern generator and timekeeper that helps test conservative hypotheses about when and how plasticity windows open.

Claim. The core claim concerns Acquired‑Savant mechanics: (i) a fast LC “network‑reset” opens a transient plasticity window; (ii) game‑loop stimuli + mild neuromodulation provide safe drive to consolidate a pre‑existing latent template (music, number patterns) in few repetitions; (iii) microbiome–vagus–LC state modulates the quality of the reset (phasic learning vs. tonic stress). The web‑biofilm Dust‑Betti thread, while secondary, adds structured motifs and objective timing for controlled, preregistered tests.