The Nucleotide Square: a Simple Geometric Representation of Genomic Composition

This work introduces the Nucleotide Square, a simple geometric framework for representing and comparing genomic composition.
Each genome is described by two normalized coordinates, x=T+C and y=G+Cy, which define its position within a square whose median lines (x = 0.5, y = 0.5) correspond to the compositional equilibrium predicted by Chargaff’s first parity rule.
The model allows genomes of any type—viral, bacterial, or eukaryotic—to be plotted and compared within a unified 2D space, providing both visual and quantitative insights into compositional biases.
Distances and deviations from the center express the magnitude of asymmetry, while quadrant positions indicate the dominant base domain.
The Nucleotide Square thus offers an intuitive yet quantitative approach for comparative genome exploration and educational purposes.
All data and calculations are fully included within the document.