Aminophylline induces two types of arrhythmic events in human pluripotent stem cell-derived cardiomyocytes - Dataset
Authors/Creators
- 1. CEITEC, Masaryk University, Brno, Czech Republic;
- 2. Department of Respiratory Diseases, Faculty of Medicine, Masaryk University, University Hospital Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech Republic;
- 3. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; First Department of Internal Medicine – Cardioangiology, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic
- 4. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic;
- 5. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic;
- 6. Faculty of Medicine, Masaryk University, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; First Department of Internal Medicine – Cardioangiology, Faculty of Medicine, Masaryk University, St. Anne's University Hospital, Brno, Czech Republic
- 7. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
- 8. Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic;
- 9. Department of Respiratory Diseases, Faculty of Medicine, Masaryk University, University Hospital Brno, Czech Republic
Description
This dataset contains raw and processed AFM data of measuring the contractility activity of 3D clusters of cardiomyocytes (Embryoid bodies) after administrating bronchodilator Aminophylline in increasing concentration. Dataset is coupled with journal article:''Aminophylline induces two types of arrhythmic events in human pluripotent stem cell-derived cardiomyocytes'' published in Frontiers in Pharmacology (https://doi.org/10.3389/fphar.2021.789730).
Some data from the original dataset was also used in the article "Integrated analysis of Cardiomyocyte Mechanical and Electrical Function: Open Source Scripts for AFM and MEA Data Characterization". Additional data used in this article (Electromechanical coupling data, artificial data) was added in version 2.0 (see changelog).
Changelog:
2.0
-Addition of results of HL-1 cells measurement including a multielectrode array (MEA) and Calcium sparklings measurements.
-Removing of Barium measurements data
3.0
-Addition of data used used in the article "A Comprehensive System of Algorithms for Characterization of Cardiomyocyte Mechanical and Electrical Function".
4.0
-Addition of data used used in the revised version of article "A Comprehensive System of Algorithms for Characterization of Cardiomyocyte Mechanical and Electrical Function".
Notes
Funding: This work was supported by the Ministry of Health of the Czech Republic, grant nr. NU20-06-00156. Acknowledgments: CIISB, Instruct-CZ Centre of Instruct-ERIC EU consortium, funded by MEYS CR infrastructure project LM2023042 and European Regional Development Fund-Project „UP CIISB“ (No. CZ.02.1.01/0.0/0.0/18_046/0015974), is gratefully acknowledged for the financial support of the measurements at the CF Nanobiotechnology.
Files
dataset_paper_revised.zip
Files
(114.2 MB)
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Additional details
Related works
- Is supplement to
- Preprint: 10.2139/ssrn.4784992 (DOI)
Software
- Repository URL
- https://github.com/DaniilKabanov/CardioScripts
- Programming language
- Python
- Development Status
- Active