DBM/VBM-derived Atrophy Pattern Maps of Frontotemporal Dementia variants (bvFTD, svPPA, nfvPPA)

The files contain voxel-wise beta estimate and t-statistics maps contrasting deformation based morphometry (DBM) and voxel-based morphometry (VBM), and vertex-wise Cortical Thickness measurements of frontotemporal dementia (FTD) patients, separated by subtype diagnosis, against healthy controls. Age, Sex and Total Intracranial Volume were added as covariates in the model.

regional_results_all.csv contains regional results for the same model, based on regions of the CerebrA atlas. Methods included are DBM = indirect DBM, dirDBM = direct DBM, VBMindir = indirect VBM, VBMdir = direct VBM, CT = Cortical Thickness, Vol = FreeSurfer volumes.

BV = behavioral-variant Frontotemporal Dementia

SV = semantic-variant Primary Progressive Aphasia

PNFA = non-fluent-variant Primary Progressive Aphasia

FTD map is based on NIFD data, available at: https://ida.loni.usc.edu/login.jsp

DBM and VBM measures were derived using the PELICAN pipeline, Cortical Thickness and Volumes were derived using FreeSurfer version 7.4.1.

Maps have been linearly and nonlinearly registered to MNI-ICBM152 space. Nonlinear registration was performed either directly (individual -> ICBM, dirVBM/dirDBM files) or indirectly through a disease-specific template (individual -> FTD template -> ICBM, indirVBM/indirDBM files). 

For more information regarding the participants and method details, see: