Data - Structural Basis of Glycoform Selectivity in Prion Strains

Molecular dynamics trajectories of mouse prion fibrils RML and ME7 with distinct glycosylation patterns:

1. Unglycosylated
2. Glycosylated at N180 and N196 with sialylated glycans
3. Glycosylated at N180 and N196 with unsialylated glycans

Molecular dynamics trajectories are saved as PyMOL sessions. Each PyMOL sessions contains three replicas corresponding to 500 ns of simulation, saved with an even stride of 50 ns (ten frames per replica).
Prion fibrils are represented as grey cartoons, glycans as lines with the following color-code: GlcNAc in blue, Fuc in red, Gal in yellow, and Sia in purple