COMPARISON OF VAGINAL FLUID CREATININE FOR THE DIAGNOSIS OF PREMATURE RUPTURE OF MEMBRANES (PROM)

Background : Premature rupture of membranes (PROM) is a common obstetric complication, contributing significantly to maternal and neonatal morbidity and mortality. Timely and accurate diagnosis is critical to guide appropriate management and reduce adverse outcomes. Traditional diagnostic methods such as the nitrazine test, fern test, and pooling are limited by their subjectivity and susceptibility to false results. Therefore, the search for a reliable, rapid, and cost-effective diagnostic marker continues. Creatinine, a constituent of amniotic fluid, is present in higher concentrations than in vaginal secretions. Measurement of vaginal fluid creatinine has emerged as a promising alternative for confirming PROM due to its biochemical specificity and ease of testing.

Objective :This study evaluates vaginal fluid creatinine level in confirmed case of PROM and women without PROM, sensitivity and specificity of vaginal fluid creatinine in diagnosis of PROM And maternal and fetal outcome in women with PROM .

Materials and Methods: A Cross-sectional analytical study was conducted from january 2023 to March 2025 at Dept. of Obstetrics and Gynecology, Dr. BRAM Hospital, Raipur (C.G),involving128 pregnant women (64 PROM, 64 controls) between 28-40 weeks gestation. Creatinine levels in vaginal fluid were measured using the Jaffe method.