EXPERIMENTAL EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF A NEW INVESTIGATED SUBSTANCE IN LABORATORY ANIMALS

Abstract

This study investigated the anti-inflammatory activity of polysaccharides derived from Capparis spinosa L. buds in laboratory animals. The experiments were conducted using a model of serotonin-induced aseptic arthritis in non-pedigree male albino rats. The test substances were administered orally at doses ranging from 25.0 to 200.0 mg/kg, and their efficacy was compared with the non-steroidal anti-inflammatory drug Dicloberl retard.

The obtained results demonstrated that the efficacy of the polysaccharides from Capparis spinosa L. buds is directly dose-dependent, with all administered doses showing significant anti-inflammatory effects. The optimal therapeutic action was observed in the 100.0-150.0 mg/kg range, where the results were equivalent to, and in some instances superior to, the efficacy of the reference drug Dicloberl retard. In long-term observations (10 days), the anti-inflammatory activity of the polysaccharides remained at a high level.

The research findings provide a scientific basis for the potential development of new, effective, and relatively safe natural anti-inflammatory drugs based on polysaccharides from Capparis spinosa L. buds.