Articulate In Addition To Emancipate Behavior Of Long-Acting Dexlansoprazole Grid Tablets

Objective: The aim of the present study was to develop sustained release formulation of Dexlansoprazole

Methodology: This Study was performed in department of Pharmaceutics by using various methods, materials, tools, and process to maintain constant therapeutic levels of the drug for over 24 hrs. By using different ratios of synthetic polymers like HPMC K100M, Ethyl cellulose Natural polymer like Xanthan gum was employed as polymers.

Results: The present work was designed to developing Sustained tablets of Dexlansoprazole using various polymers. All the formulations were evaluated for physicochemical properties and in vitro drug release studies. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired drug release pattern i.e., 96.61% in 24 hours. It contains the HPMC K100M 1:3 ratio as sustained release material. It followed Higuchi release kinetics mechanism.

Conclusion: The present study concludes that sustained drug delivery of Dexlansoprazole can be a good way to prolong duration of action of drug by reducing the dosing frequency of Dexlansoprazole. Present study concludes that Sustained drug delivery system should be a suitable method for Dexlansoprazole administration. The optimised formulation was found to be F3 formulation.