Microbial Etiology and Antimicrobial Resistance Patterns in Hip and Knee Prosthetic Joint Infections: A Cross-Sectional Study from A Tertiary Care Centre

Introduction: Joint infections, also known as septic arthritis, remain a serious orthopedic emergency requiring prompt diagnosis and intervention. The increasing incidence of antimicrobial resistance complicates management strategies, especially in prosthetic joint infections.

Aim and Objectives: To determine the microbiological spectrum, resistance patterns, and clinical outcomes of joint infections in a tertiary care setting.

Material and Methods: This was a Cross sectional observational study conducted in the Department of Orthopaedics for a period of 12 months i.e, May 2024 to May 2025, involving patients with clinically and microbiologically confirmed joint infections. Clinical data, laboratory investigations, and microbial cultures were evaluated to identify common pathogens and antibiotic susceptibility profiles.

Results: The majority of infections were caused by Staphylococcus aureus, including methicillin-resistant strains (MRSA), followed by Gram-negative organisms like Pseudomonas aeruginosa and Klebsiellapneumoniae. High resistance was observed to commonly used antibiotics, necessitating tailored therapy. Early diagnosis and targeted therapy significantly improved outcomes.

Conclusion: Joint infections demand urgent diagnosis and management. Rising antibiotic resistance underscores the importance of surveillance and antimicrobial stewardship programs.