HISTOLOGICAL REMODELING OF THE THYMUS UNDER STRESS-INDUCED SECONDARY IMMUNODEFICIENCY

The increasing prevalence of psychosocial stressors, malnutrition, and environmental factors has significantly contributed to the development of secondary immunodeficiency worldwide.

The thymus, as the central organ of T-lymphocyte maturation, is one of the most stress-sensitive structures. Understanding thymic morphological damage under stress is crucial for early diagnosis, prevention, and development of therapeutic strategies in clinical immunology and pathomorphology.