ULCEROGENIC EFFECT OF DICLOFENAC COMPLEX COMPOUNDS AND BIOMETALS

Diclofenac is a widely used nonsteroidal anti-inflammatory drug (NSAID) with high therapeutic efficacy but also significant ulcerogenic potential. In this paper, the possibility of modifying diclofenac through complexation with biometals (such as zinc, nickel) is considered in order to reduce its gastrotoxicity and develop new forms with an improved safety profile. Preclinical studies of the obtained compounds using a model of ulceration in laboratory animals have been carried out.