EPIC-unmix

EPIC-unmix is a two-step Bayesian method designed for cell-type-specific (CTS) analysis built upon the bMIND method. Similarly, it can provide sample-level CTS expression from the bulk RNA-seq data, with the aid of a reference panel derived from single-cell/single-nuclei RNA-seq data. The second layer of Bayesian method, which distinguishes EPIC-unmix from bMIND, could adjust for the heterogeneity between reference and target samples, leading to more enhanced and robust performance.