EWCL–MobiDB Benchmarks 2025: DisProt, IDEAL, Merge, UniProt, and Binding Snapshots

Legacy EWCLv1 benchmark (2025). This record contains results from an earlier EWCL model and is not the dataset for the current EWCL manuscript. Public access to the legacy files has been restricted at the depositor's request while a separate complete release is prepared. The original DOI and historical description are retained for provenance.

This dataset provides per-residue and per-protein benchmark tables for EWCLv1 (Entropy-Weighted Collapse Likelihood) evaluated against the MobiDB curated disorder references — DisProt, IDEAL, Merge, and UniProt — as well as the derived Binding Disorder–Disorder (D→D) snapshot.

EWCL quantifies local conformational entropy and thermodynamic confidence directly from sequence.

Each archive includes ROC and PR plots, per-protein metrics, and summary JSONs used in the EWCL-2025 study.

These benchmarks complement the EWCL–CAID Benchmarks 2025 dataset (Zenodo DOI: 10.5281/zenodo.17352525), which provides CAID-aligned disorder, linker, and binding evaluations.

Contents

• EWCL_MOBIDB_2025_Disprot.zip — DisProt reference (full curated set)

• EWCL_MOBIDB_2025_IDEAL_excl_Disprot.zip — IDEAL benchmark excluding DisProt overlap

• EWCL_MOBIDB_2025_Merge_excl_Disprot.zip — MobiDB Merge benchmark excluding DisProt overlap

• EWCL_MOBIDB_2025_UniProt_excl_Disprot.zip — UniProt benchmark excluding DisProt overlap

• EWCL_MOBIDB_2025_Binding_DD.zip — Non-homology Binding Disorder–Disorder (D→D priority) snapshot

Each ZIP contains:

data/ (residue- and protein-level CSVs),

figs/ (ROC and PR curves), and

meta/summary.json (micro/macro AUCs, F1, prevalence)