Published October 24, 2025 | Version 1.0
Dataset Open

Unified Human Gut Virome (UHGV)

Creators

  • 1. ROR icon Joint Genome Institute

Description

The UHGV is a comprehensive genomic resource of viruses from the human gut microbiome. Genomes were derived from 12 independent data sources and annotated using a uniform bioinformatics pipeline.

The files in this repository, which are described below, contain the most relevant data for most users. For the remaining data, please see: https://uhgv.jgi.doe.gov/downloads

File Description
uhgv_full.fna.zst Genomic sequences of all viruses (n=873,995) in UHGV, including the ones with uncertain virus prediction
uhgv_full.faa.zst Protein sequences (n=37,443,649) of all viruses in UHGV, including the ones with uncertain virus prediction
votus_full.fna.zst Genomic sequences of vOTU representatives (n=168,536)
votus_full.faa.zst Protein sequences (n=7,426,124) of vOTU representatives
uhgv_metadata.tsv.zst Metadata for each of the 873,995 UHGV genomes
votus_metadata_extended.tsv.zst Metadata for the 168,536 species-level viral clusters (vOTUs)
source_biosample_metadata.tsv.zst Information for the samples from which virus genomes were obtained
host_range_breadth.tsv.zst Estimated host range breadth for 72,503 vOTUs
read_mapping_relative_abundances.tsv.zst Per-sample relative abundances of viruses and hosts derived from read mapping data
read_mapping_sample_metadata.tsv.zst Metadata describing the samples used for viral profiling through read mapping (e.g., country, lifestyle, age, gender, BMI, study)
read_mapping_study_metadata.tsv.zst Study-level metadata for the sources from which samples were obtained for viral profiling through read mapping

Files

Files (8.8 GB)

Name Size Download all
md5:25960f854fa411956ef1353213133bfc
490.6 kB Download
md5:e6d9feb8e7e583076c2a8fa88ee354f1
11.0 MB Download
md5:98df06e9bd17f6c0d1fd374fcea6763d
69.8 kB Download
md5:be82bec4d0650b6af42ab7301c4d5332
5.1 kB Download
md5:9934204a79cdac60ce9681a6233282b6
152.1 kB Download
md5:d2120a8c5f39e83092e087b551614142
5.1 GB Download
md5:6608f58dbd0e451c9a494ccf69cb3a35
1.7 GB Download
md5:f897bdf92b8b93cf3941f6d2c3d55efb
39.0 MB Download
md5:1eff9626a8c3990a98d2b4ea58ff0596
1.0 GB Download
md5:9ad996fea08c6087a452194f0c2f9d33
964.7 MB Download
md5:6702355349e933fb605e62a8bbaa50a9
14.0 MB Download

Additional details

Compiles
Publication: 10.1038/s41564-021-00928-6 (DOI)
Publication: 10.1016/j.chom.2019.08.008 (DOI)
Publication: 10.1016/j.chom.2020.08.003 (DOI)
Publication: 10.1016/j.cell.2021.01.029 (DOI)
Publication: 10.1016/j.celrep.2021.109132 (DOI)
Publication: 10.1073/pnas.2023202118 (DOI)
Publication: 10.1128/mSystems.00382-21 (DOI)
Publication: 10.1186/s40168-021-01017-w (DOI)
Publication: 10.1093/nar/gkaa869 (DOI)
Publication: 10.1093/nar/gkac1037 (DOI)
Publication: 10.1038/s41564-023-01345-7 (DOI)
Publication: 10.1016/j.cell.2023.05.046 (DOI)

Software

Repository URL
https://github.com/snayfach/UHGV