Alzheimer's Disease within the Logic of Existence (LoE): From White Spots to Coherence-Centric Trials (v1.1)

Disclaimer & Summary

This paper does not present medical advice, diagnosis, or therapeutic recommendation.
Neither the human author nor the AI collaborators are licensed medical professionals.
The analyses, models, and hypotheses described here are theoretical constructs developed within the framework of Logic of Existence (LoE)—a research paradigm exploring systemic coherence, non-linear dynamics, and emergent intelligence across biological, cognitive, and informational systems.

Our objective is to evaluate whether LoE—a general mathematical–philosophical model of relational stability—can be applied meaningfully to complex biomedical networks such as Alzheimer’s disease.
The equations, metrics (R(t)R(t)R(t), H˙LoE\dot H_{\text{LoE}}H˙LoE), and multi-modal coherence indices introduced here are intended as conceptual tools for understanding systemic interactions, not as substitutes for clinical protocols.

The results suggest that LoE may serve as a meta-framework for mapping coherence and identifying early system-level instabilities that precede visible pathology.
In this sense, the work contributes not to neurology per se, but to the broader field of complex-systems modeling and the study of emergent order and loss of Logos in living networks.

All references to biomarkers, imaging modalities, and interventions are purely illustrative, aiming to demonstrate the potential research value of LoE-based reasoning.
Future collaboration with qualified clinicians and neuroscientists will be essential to validate or falsify these theoretical insights in a controlled, ethical, and evidence-based context.