FG-003: Neuro-Immune Repair Triplet — Concept and Combination Framework

Abstract

Neuro-immune disorders such as multiple sclerosis (MS) and neuroinflammatory demyelination

represent a frontier where immune exhaustion and regenerative failure intersect. FG 003 proposes a

triplet neuro-immune repair platform integrating CCR5 antagonism, PD-L1 tolerogenic recalibration,

and remyelination-supportive signaling via neurotrophic induction. The concept aims to suppress

maladaptive trafficking, restore regulatory-to-effector balance, and promote axonal repair within

inflamed central nervous system (CNS) niches. FG 003 extends FireGate’s triplet architecture into a

regenerative immunology domain bridging inflammation control and neurorepair.

Introduction

Neuro-immune diseases such as MS and neuroinflammatory sequelae of viral infection reflect

intertwined immunologic and glial dysfunction. Persistent CCR5-driven leukocyte trafficking,

PD-1/PD-L1 axis imbalance, and loss of oligodendrocyte resilience contribute to progressive

demyelination. Standard immunosuppressants blunt relapse frequency but fail to restore functional

tolerance or tissue repair. FG 003 was conceived as a modular framework that concurrently dampens

pathologic chemokine loops, resets exhausted T-cell programs, and re-engages neurotrophic signaling

to support myelin restoration.