Release Notes 2025-10-16

Ontology content summary

| Metric | Value | |:------------------------------------------------|--------:| | Number of subclasses of root | 3159 | | Number of annotations on CL terms | 16333 | | Number of synonyms | 6805 | | Number of unique references | 1960 | | Number of unique references in definitions | 1923 | | Number of relationships with CL term as subject | 4668 | | Number of cellxgene classes | 955 | | Number of HRA classes | 516 |

<details> <summary>Nodes renamed: 19</summary>

| ID | Old Label | New Label | ----|----|----| | CL:4023016 | VIP GABAergic cortical interneuron | VIP GABAergic interneuron | | CL:4023121 | sst chodl GABAergic cortical interneuron | sst chodl GABAergic interneuron | | CL:4047054 | migratory dendtritic cell | migratory dendritic cell | | CL:0000135 | fibrocyte | circulating fibrocyte | | CL:4023011 | lamp5 GABAergic cortical interneuron | lamp5 GABAergic interneuron | | CL:4023017 | sst GABAergic cortical interneuron | sst GABAergic interneuron | | CL:4042032 | PAX6 GABAergic cortical interneuron | PAX6 GABAergic interneuron | | CL:4023069 | medial ganglionic eminence derived GABAergic cortical interneuron | medial ganglionic eminence derived GABAergic interneuron | | CL:0000940 | mucosal invariant T cell | mucosal-associated invariant T cell | | CL:4023064 | caudal ganglionic eminence derived cortical interneuron | caudal ganglionic eminence derived interneuron | | CL:4023036 | chandelier pvalb GABAergic cortical interneuron | chandelier pvalb GABAergic interneuron | | CL:4023015 | sncg GABAergic cortical interneuron | sncg GABAergic interneuron | | CL:4023018 | pvalb GABAergic cortical interneuron | pvalb GABAergic interneuron | | CL:4307026 | Bergman glial cell (Mmus) | Bergmann glial cell (Mmus) | | CL:0002040 | immature NK T cell stage II | immature NK T cell stage II, mouse | | CL:0000293 | structural cell | obsolete structural cell | | CL:0002039 | immature NK T cell stage I | immature NK T cell stage I, mouse | | CL:0002041 | immature NK T cell stage III | immature NK T cell stage III, mouse | | CL:0002042 | immature NK T cell stage IV | immature NK T cell stage IV, mouse |

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<details> <summary>Text definitions changed: 57</summary>

| Term | Old Text Definition | New Text Definition | ----|----|----| | acinar cell of salivary gland (CL:0002623) | An acinar cell of salivary gland. | An acinar cell that is part of the salivary gland epithelium, responsible for synthesizing and secreting the primary saliva essential for oral digestion, antimicrobial defense, and mucosal immunity. It features apical-basal polarity with apical secretory granules, and tight junctions that maintain polarity and regulate calcium-dependent saliva exocytosis triggered by parasympathetic and sympathetic signals (Ambudkar, 2015). This cell functions in coordination with contractile myoepithelial cells, which aid saliva flow through the ducts into the oral cavity (Khan et al., 2022). In mice and humans, acinar cell development relies on the transcription factor SOX2 (Emmerson et al., 2017), with self-renewal achieved primarily through acinar cell self-duplication and supported by progenitor populations during injury and regeneration (Aure et al., 2016). | | fraction A pre-pro B cell (CL:0002045) | A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. | A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. | | fraction F mature B cell (CL:0002056) | A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative. | A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative. | | immature NK T cell stage III, mouse (CL:0002041) | A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell. | A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell. | | mucosal-associated invariant T cell (CL:0000940) | An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. | An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. This cell develops from double-positive, alpha-beta thymocyte. | | GABA-Glut neuron (CL:0008060) | A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters. | A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters. | | Lamp5 Lhx6 neuron (CL:4042013) | A transcriptomically distinct lamp5 GABAergic cortical interneuron located in the cerebral cortex that expresses Lamp5 and Lhx6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6. | A transcriptomically distinct GABAergic interneuron marked by Lamp5 and Lhx6 expression, derived from the Medial Ganglionic Eminence (MGE), and located in the pallium. | | L6 intratelencephalic projecting glutamatergic neuron (CL:4030065) | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT. | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. | | pvalb GABAergic interneuron (CL:4023018) | A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb. | A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. | | Bm3 B cell (CL:0000965) | A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type. | A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type. | | L6 intratelencephalic projecting Car3 glutamatergic neuron (CL:4030068) | A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6 . The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3. | A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6. | | keratinized cell of hair follicle (CL:0010000) | A hair follicle matrix region cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the hair bulb to become the hair medulla cortex and hair root sheath. | A differentiating matrix keratinocyte that has initiated terminal differentiation and keratin synthesis. This cell undergoes a characteristic change while migrating upward from the hair follicle bulb, representing a committed progenitor cell destined to form the hair medulla, cortex and hair root sheath. | | Bm2 B cell (CL:0000962) | A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells. | A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells. | | fraction C precursor B cell (CL:0002049) | A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain. | A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain. | | L6 corticothalamic-projecting glutamatergic cortical neuron (CL:4023042) | A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT. | A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. | | chandelier pvalb GABAergic interneuron (CL:4023036) | A transcriptomically distinct pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier. | A transcriptomically distinct pvalb GABAergic interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner. | | lamp5 GABAergic interneuron (CL:4023011) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5. | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. | | obsolete structural cell (CL:0000293) | A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. | OBSOLETE. A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. | | L5 extratelencephalic projecting glutamatergic cortical neuron (CL:4023041) | A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET. | A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. | | VIP GABAergic interneuron (CL:4023016) | A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip. | A transcriptomically distinct GABAergic neuron derived from the CGE and that expresses the vasoactive intestinal polypeptide. Its soma is located in the forebrain. | | Bm4 B cell (CL:0000966) | A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor. | A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor. | | immature NK T cell stage II, mouse (CL:0002040) | A CD24-low, CD44-negative, NK1.1-negative NK T cell. | A CD24-low, CD44-negative, NK1.1-negative NK T cell. | | fraction E immature B cell (CL:0002054) | An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive. | An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive. | | trabecular meshwork cell (CL:0002367) | A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure. | An ocular connective tissue cell that is part of the eye's trabecular meshwork and is directly responsible for regulating the outflow of aqueous humor from the anterior chamber of the eye, thereby maintaining proper intraocular pressure. | | immature NK T cell stage I, mouse (CL:0002039) | A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. | A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. | | Bm1 B cell (CL:0000961) | A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells. | A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells. | | enterocyte of epithelium of large intestine (CL:0002071) | Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type. | A columnar absorptive epithelial cell found in the epithelium of large intestine, specialized for water and electrolyte absorption. Unlike small intestinal enterocytes, those in the large intestine have fewer apical microvilli. | | sst chodl GABAergic interneuron (CL:4023121) | A transcriptomically distinct sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl. | A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection. | | CD11c-low plasmacytoid dendritic cell (CL:0000989) | CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative. | CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative. | | Vgamma1.1-positive, Vdelta6.3-negative thymocyte (CL:0002411) | A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor. | A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor. | | Bm5 B cell (CL:0000967) | A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes. | A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes. | | Gr1-high classical monocyte (CL:0002395) | A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative. | A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative. | | Schlemm's canal endothelial cell (CL:4033097) | A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2016). | A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2015). | | L2/3 intratelencephalic projecting glutamatergic neuron (CL:4030059) | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT. | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. | | L4 intratelencephalic projecting glutamatergic neuron (CL:4030063) | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT. | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. | | sst GABAergic interneuron (CL:4023017) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst. | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst) and derived from the MGE. | | fraction B/C precursor B cell (CL:0002400) | A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive. | A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive. | | immature NK T cell stage IV, mouse (CL:0002042) | A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell. | A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell. | | suprabasal keratinocyte (CL:4033013) | A keratinocyte of the epidermis suprabasal layer. This cell may express the differentiation markers keratin 10 and keratin 1. | A keratinocyte that resides in the epidermal suprabasal layer and expresses differentiation markers, including keratin 1 and keratin 10, in both humans and mice. In human interfollicular epidermis, this cell retains proliferative capacity and possesses retrodifferentiation potential, acquiring basal-like properties during wound healing or basement membrane contact. | | choroidal cell of the eye (CL:0000348) | A structural cell that is part of optic choroid. | A cell that is part of optic choroid. | | Gr1-positive, CD43-positive monocyte (CL:0002398) | An intermediate monocyte that is Gr1-positive, CD43-positive. | An intermediate monocyte that is Gr1-positive, CD43-positive. | | L5/6 near-projecting glutamatergic neuron (CL:4030067) | A near-projecting glutamatergic neuron with a soma found in cortical layer 5/6. | A transcriptomically defined near-projecting glutamatergic neuron with a soma found in cortical layer 5/6. | | fraction D precursor B cell (CL:0002052) | A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive. | A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive. | | Vgamma1.1-positive, Vdelta6.3-positive thymocyte (CL:0002412) | A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor. | A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor. | | L5 intratelencephalic projecting glutamatergic neuron (CL:4030064) | An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT. | An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. | | medial ganglionic eminence derived GABAergic interneuron (CL:4023069) | A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex. | A GABAergic interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex. | | otic fibrocyte (CL:0002665) | A fibrocyte of the cochlea that has specialized structural and molecular adaptions. | A mesenchymal cell of the cochlea that has specialized structural and molecular adaptions. | | PAX6 GABAergic interneuron (CL:4042032) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses the transcript PAX6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters PAX6. | A transcriptomically distinct GABAergic neuron, located in the cerebral cortex and derived from the CGE, that expresses the transcript PAX6. | | connective tissue cell (CL:0002320) | A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. | A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest. | | circulating fibrocyte (CL:0000135) | An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes. | A bone marrow-derived cell that predominantly develops from myeloid lineage-restricted progenitor cells and circulates in peripheral blood, characterized by co-expression of hematopoietic markers CD45 and CD34 along with stromal markers including collagen type I in both humans and mice (Chesney et al., 1997; Blakaj and Bucala, 2012). This spindle-shaped cell exhibits a unique dual identity, functionally bridging immune and stromal compartments with characteristics of both monocytes and fibroblasts. Predominantly arising from circulating monocytes, it migrates to injury sites via chemokine receptors and participates in wound repair through extracellular matrix deposition, cytokine secretion, and antigen presentation via MHC class II. As mesenchymal progenitors, fibrocytes can differentiate into fibroblasts, myofibroblasts, and adipocytes, contributing to both physiological repair and pathological fibrosis (Blakaj and Bucala, 2012). | | CD11c-negative plasmacytoid dendritic cell (CL:0000991) | CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive. | CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive. | | fraction C' precursor B cell (CL:0002050) | A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive. | A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive. | | L6b glutamatergic cortical neuron (CL:4023038) | A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b. | A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. | | tendon cell (CL:0000388) | An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance. | An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance. | | Bm2' B cell (CL:0000964) | A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative. | A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative. | | sncg GABAergic interneuron (CL:4023015) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg. | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. | | fraction B precursor B cell (CL:0002047) | A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative. | A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative. |

</details>

<details> <summary>Relationships added: 202</summary>

| Subject | Predicate | Object| ----|----|----| | mucosal-associated invariant T cell, human (CL:0020002) | RO:0002104 | PR:A0A0B4J238 | | corticotropin-releasing neuron (CL:4072021) | subClassOf (rdfs:subClassOf) | adrenocorticotropic hormone secreting cell (CL:0000467) | | G4 retinal ganglion cell (CL:0003005) | RO:0002162 | NCBITaxon:9986 | | agouti-related protein expressing neuron (CL:4072017) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | SCN pacemaker neuron (CL:4072019) | subClassOf (rdfs:subClassOf) | neuron of the forebrain (CL:0012001) | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | subClassOf (rdfs:subClassOf) | chandelier pvalb GABAergic interneuron (CL:4023036) | | juxtacanalicular tissue cell (CL:7770002) | subClassOf (rdfs:subClassOf) | extracellular matrix secreting cell (CL:0000327) | | lower motor neuron (CL:0008039) | RO:0002162 | NCBITaxon:7742 | | retinal ganglion cell D1 (CL:0003026) | RO:0002162 | NCBITaxon:10090 | | interneuron (CL:0000099) | BFO:0000050 | UBERON:0001017 | | agouti-related protein expressing neuron (CL:4072017) | RO:0002100 | UBERON:0001932 | | agouti-related protein expressing neuron (CL:4072017) | RO:0002292 | PR:000011387 | | dental papilla cell (CL:0000345) | subClassOf (rdfs:subClassOf) | eukaryotic cell (CL:0000255) | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | subClassOf (rdfs:subClassOf) | L4 intratelencephalic projecting glutamatergic neuron (CL:4030063) | | gut mesenchymal lymphoid tissue organizer cell (CL:0020000) | subClassOf (rdfs:subClassOf) | stromal cell (CL:0000499) | | optic choroid fibroblast (CL:2000070) | subClassOf (rdfs:subClassOf) | choroidal cell of the eye (CL:0000348) | | gut mesenchymal lymphoid tissue organizer cell (CL:0020000) | subClassOf (rdfs:subClassOf) | mesenchymal stem cell (CL:0000134) | | serous acinar cell of salivary gland (CL:4052065) | subClassOf (rdfs:subClassOf) | acinar cell of salivary gland (CL:0002623) | | V1delta gamma-delta T cell (CL:0020001) | subClassOf (rdfs:subClassOf) | mature gamma-delta T cell (CL:0000800) | | rosehip neuron (CL:0008032) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | subClassOf (rdfs:subClassOf) | L5/6 near-projecting glutamatergic neuron (CL:4030067) | | L5 non-Martinotti sst GABAergic interneuron (Mmus) (CL:4023028) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | NPY interneuron (CL:4072016) | RO:0002292 | PR:000011387 | | small intestine serosal dendritic cell (CL:0002466) | BFO:0000050 | UBERON:0001206 | | PAX6 GABAergic interneuron (Homo sapiens) (CL:4072036) | RO:0002162 | NCBITaxon:9606 | | G11 retinal ganglion cell (CL:0003014) | RO:0002162 | NCBITaxon:9986 | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | agouti-related protein expressing neuron (CL:4072017) | subClassOf (rdfs:subClassOf) | neuron of the forebrain (CL:0012001) | | M2 retinal ganglion cell (CL:0003029) | RO:0002162 | NCBITaxon:10090 | | acinar cell of salivary gland (CL:0002623) | BFO:0000051 | GO:0030141 | | G3 retinal ganglion cell (CL:0003004) | RO:0002162 | NCBITaxon:9986 | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | optic choroid fibroblast (CL:2000070) | subClassOf (rdfs:subClassOf) | neural crest derived fibroblast (CL:0000005) | | G7 retinal ganglion cell (CL:0003010) | RO:0002162 | NCBITaxon:9986 | | L5/6 non-Martinotti sst GABAergic interneuron (Mmus) (CL:4023118) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | subClassOf (rdfs:subClassOf) | sncg GABAergic interneuron (CL:4023015) | | medium spiny neuron (CL:1001474) | subClassOf (rdfs:subClassOf) | lateral ganglionic eminence derived neuron (CL:4023035) | | M4 retinal ganglion cell (CL:0003033) | RO:0002162 | NCBITaxon:10090 | | medulla-projecting glutamatergic neuron of the primary motor cortex (CL:4023045) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | NPY interneuron (CL:4072016) | subClassOf (rdfs:subClassOf) | GABAergic interneuron (CL:0011005) | | Lamp5 Lhx6 neuron (CL:4042013) | subClassOf (rdfs:subClassOf) | medial ganglionic eminence derived GABAergic interneuron (CL:4023069) | | circulating fibrocyte (CL:0000135) | RO:0002202 | myeloid lineage restricted progenitor cell (CL:0000839) | | retinal ganglion cell C (CL:0004116) | RO:0002162 | NCBITaxon:10090 | | Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) (CL:4072022) | RO:0002162 | NCBITaxon:9606 | | Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) (CL:4072022) | subClassOf (rdfs:subClassOf) | Lamp5 Lhx6 neuron (CL:4042013) | | Gr1-high classical monocyte (CL:0002395) | RO:0002162 | NCBITaxon:10090 | | circulating fibrocyte (CL:0000135) | subClassOf (rdfs:subClassOf) | progenitor cell (CL:0011026) | | suprabasal keratinocyte (CL:4033013) | subClassOf (rdfs:subClassOf) | suprabasal cell (CL:7770004) | | quiescent fibroblast (CL:4052071) | subClassOf (rdfs:subClassOf) | fibroblast (CL:0000057) | | G9 retinal ganglion cell (CL:0003012) | RO:0002162 | NCBITaxon:9986 | | retinal ganglion cell A (CL:0004117) | RO:0002162 | NCBITaxon:10090 | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | subClassOf (rdfs:subClassOf) | L6b glutamatergic cortical neuron (CL:4023038) | | internal globus pallidus core projecting neuron (CL:0020003) | RO:0002292 | PR:000013502 | | M12 retinal ganglion cell (CL:0003045) | RO:0002162 | NCBITaxon:10090 | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | beam B cell, human (CL:7770006) | RO:0002162 | NCBITaxon:9606 | | hippocampal neuron (CL:0002608) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | M11 retinal ganglion cell (CL:0003044) | RO:0002162 | NCBITaxon:10090 | | nail matrix keratinocyte (CL:4052064) | BFO:0000050 | UBERON:0002283 | | CD11c-negative plasmacytoid dendritic cell (CL:0000991) | RO:0002162 | NCBITaxon:9606 | | Vgamma1.1-positive, Vdelta6.3-positive thymocyte (CL:0002412) | RO:0002162 | NCBITaxon:10090 | | M7 retinal ganglion cell (CL:0003036) | RO:0002162 | NCBITaxon:10090 | | acinar cell of salivary gland (CL:0002623) | RO:0002215 | GO:0045087 | | M10 retinal ganglion cell (CL:0003043) | RO:0002162 | NCBITaxon:10090 | | gut mesenchymal lymphoid tissue organizer cell (CL:0020000) | subClassOf (rdfs:subClassOf) | progenitor cell (CL:0011026) | | mucous acinar cell of salivary gland (CL:4052066) | subClassOf (rdfs:subClassOf) | mucus secreting cell (CL:0000319) | | mucous acinar cell of salivary gland (CL:4052066) | BFO:0000050 | UBERON:0014717 | | tendon cell (CL:0000388) | subClassOf (rdfs:subClassOf) | fibroblast of dense regular elastic tissue (CL:1000307) | | G10 retinal ganglion cell (CL:0003013) | RO:0002162 | NCBITaxon:9986 | | excretory duct cell of salivary gland (CL:4052069) | BFO:0000050 | UBERON:0035049 | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | RO:0002162 | NCBITaxon:9606 | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | subClassOf (rdfs:subClassOf) | L6 corticothalamic-projecting glutamatergic cortical neuron (CL:4023042) | | nail bed keratinocyte (CL:4052063) | subClassOf (rdfs:subClassOf) | epidermal keratinocyte (CL:4052061) | | L5/6 cck GABAergic interneuron (Mmus) (CL:4023071) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | subClassOf (rdfs:subClassOf) | L6 intratelencephalic projecting glutamatergic neuron (CL:4030065) | | suprabasal cell (CL:7770004) | subClassOf (rdfs:subClassOf) | epithelial cell (CL:0000066) | | NPY interneuron (CL:4072016) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | olfactory bulb tufted cell (CL:1001503) | subClassOf (rdfs:subClassOf) | central nervous system neuron (CL:2000029) | | internal globus pallidus core projecting neuron (CL:0020003) | subClassOf (rdfs:subClassOf) | GABAergic neuron (CL:0000617) | | juxtacanalicular tissue cell (CL:7770002) | subClassOf (rdfs:subClassOf) | secretory cell (CL:0000151) | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | RO:0002162 | NCBITaxon:9606 | | G6 retinal ganglion cell (CL:0003009) | RO:0002162 | NCBITaxon:9986 | | fraction A pre-pro B cell (CL:0002045) | RO:0002162 | NCBITaxon:10090 | | G5 retinal ganglion cell (CL:0003008) | RO:0002162 | NCBITaxon:9986 | | L6 intratelencephalic projecting Car3 glutamatergic neuron (CL:4030068) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | mucosal-associated invariant T cell, human (CL:0020002) | lacks_plasma_membrane_part (CL:4030046) | PR:Q12918 | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | RO:0002162 | NCBITaxon:9606 | | M1 retinal ganglion cell (CL:0003028) | RO:0002162 | NCBITaxon:10090 | | PAX6 GABAergic interneuron (Homo sapiens) (CL:4072036) | subClassOf (rdfs:subClassOf) | PAX6 GABAergic interneuron (CL:4042032) | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | M8 retinal ganglion cell (CL:0003039) | RO:0002162 | NCBITaxon:10090 | | retinal ganglion cell B (CL:0004115) | RO:0002162 | NCBITaxon:10090 | | fraction B/C precursor B cell (CL:0002400) | RO:0002162 | NCBITaxon:10090 | | beam B cell, human (CL:7770006) | RO:0002292 | PR:Q9UIK5 | | meis2 expressing cortical GABAergic cell (CL:4023065) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | sst chodl GABAergic interneuron (Homo sapiens) (CL:4072031) | subClassOf (rdfs:subClassOf) | sst chodl GABAergic interneuron (CL:4023121) | | M14 retinal ganglion cell (CL:0003047) | RO:0002162 | NCBITaxon:10090 | | immature NK T cell stage I, mouse (CL:0002039) | RO:0002162 | NCBITaxon:10090 | | juxtacanalicular tissue cell (CL:7770002) | subClassOf (rdfs:subClassOf) | trabecular meshwork cell (CL:0002367) | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | subClassOf (rdfs:subClassOf) | L5 extratelencephalic projecting glutamatergic cortical neuron (CL:4023041) | | squamous cell of epidermis (CL:0002190) | subClassOf (rdfs:subClassOf) | epidermal keratinocyte (CL:4052061) | | lamp5 GABAergic interneuron (Homo sapiens) (CL:4072034) | subClassOf (rdfs:subClassOf) | lamp5 GABAergic interneuron (CL:4023011) | | serous acinar cell of salivary gland (CL:4052065) | subClassOf (rdfs:subClassOf) | serous secreting cell (CL:0000313) | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | beam A cell (CL:7770003) | subClassOf (rdfs:subClassOf) | beam cell (CL:7770005) | | L5 sst T-Martinotti interneuron (Mmus) (CL:4023027) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | oxytocin receptor sst GABAergic cortical interneuron (CL:4023122) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | M3 retinal ganglion cell (CL:0003030) | RO:0002162 | NCBITaxon:10090 | | CD11c-low plasmacytoid dendritic cell (CL:0000989) | RO:0002162 | NCBITaxon:10090 | | otic fibrocyte (CL:0002665) | subClassOf (rdfs:subClassOf) | eukaryotic cell (CL:0000255) | | excretory duct cell of salivary gland (CL:4052069) | subClassOf (rdfs:subClassOf) | duct epithelial cell (CL:0000068) | | L6 th sst GABAergic interneuron (Mmus) (CL:4023075) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | SCN pacemaker neuron (CL:4072019) | RO:0002100 | UBERON:0002034 | | dual-feature fallopian tube progenitor cell (CL:4052070) | BFO:0000050 | UBERON:8600124 | | lamp5 GABAergic interneuron (Homo sapiens) (CL:4072034) | RO:0002162 | NCBITaxon:9606 | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | subClassOf (rdfs:subClassOf) | L6 intratelencephalic projecting Car3 glutamatergic neuron (CL:4030068) | | internal globus pallidus core projecting neuron (CL:0020003) | subClassOf (rdfs:subClassOf) | neuron of the forebrain (CL:0012001) | | serous acinar cell of salivary gland (CL:4052065) | RO:0002215 | GO:0005983 | | otic fibrocyte (CL:0002665) | subClassOf (rdfs:subClassOf) | mesenchymal cell (CL:0008019) | | mature NK T cell (CL:0000814) | RO:0002202 | immature NK T cell (CL:0000914) | | seromucous acinar cell of salivary gland (CL:4052067) | subClassOf (rdfs:subClassOf) | seromucus secreting cell (CL:0000159) | | mucosal-associated invariant T cell, human (CL:0020002) | subClassOf (rdfs:subClassOf) | mucosal-associated invariant T cell (CL:0000940) | | G1 retinal ganglion cell (CL:0003002) | RO:0002162 | NCBITaxon:9986 | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | RO:0002162 | NCBITaxon:9606 | | respiratory tract suprabasal cell (CL:4033048) | subClassOf (rdfs:subClassOf) | suprabasal cell (CL:7770004) | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | L4 sst Martinotti interneuron (Mmus) (CL:4023031) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | agouti-related protein expressing neuron (CL:4072017) | RO:0002292 | PR:000003846 | | internal globus pallidus shell projection neuron (CL:0020004) | RO:0002100 | UBERON:0002477 | | M13 retinal ganglion cell (CL:0003046) | RO:0002162 | NCBITaxon:10090 | | mucous acinar cell of salivary gland (CL:4052066) | subClassOf (rdfs:subClassOf) | acinar cell of salivary gland (CL:0002623) | | seromucous acinar cell of salivary gland (CL:4052067) | subClassOf (rdfs:subClassOf) | acinar cell of salivary gland (CL:0002623) | | alpha7 GABAergic cortical interneuron (Mmus) (CL:4023010) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | subClassOf (rdfs:subClassOf) | sst GABAergic interneuron (CL:4023017) | | corticotropin-releasing neuron (CL:4072021) | subClassOf (rdfs:subClassOf) | neuroendocrine cell (CL:0000165) | | circulating fibrocyte (CL:0000135) | RO:0002215 | GO:0042060 | | beam cell (CL:7770005) | subClassOf (rdfs:subClassOf) | phagocyte (CL:0000234) | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | RO:0002162 | NCBITaxon:9606 | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | RO:0002162 | NCBITaxon:9606 | | pacemaker neuron (CL:4072018) | subClassOf (rdfs:subClassOf) | neuron (CL:0000540) | | Bm1 B cell (CL:0000961) | lacks_plasma_membrane_part (CL:4030046) | PR:000001880 | | beam B cell, human (CL:7770006) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | nail bed keratinocyte (CL:4052063) | BFO:0000050 | UBERON:0005273 | | internal globus pallidus core projecting neuron (CL:0020003) | RO:0002100 | UBERON:0002477 | | corticotropin-releasing neuron (CL:4072021) | subClassOf (rdfs:subClassOf) | interneuron (CL:0000099) | | mature T cell (CL:0002419) | RO:0000053 | PATO:0001701 | | retinal ganglion cell D2 (CL:0003027) | RO:0002162 | NCBITaxon:10090 | | pvalb GABAergic interneuron (Homo sapiens) (CL:4072029) | subClassOf (rdfs:subClassOf) | pvalb GABAergic interneuron (CL:4023018) | | internal globus pallidus shell projection neuron (CL:0020004) | subClassOf (rdfs:subClassOf) | neuron of the forebrain (CL:0012001) | | Vgamma1.1-positive, Vdelta6.3-negative thymocyte (CL:0002411) | RO:0002162 | NCBITaxon:10090 | | reelin GABAergic cortical interneuron (CL:4032001) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | RO:0002162 | NCBITaxon:9606 | | thymic plasmacytoid dendritic cell (CL:0000942) | BFO:0000050 | UBERON:0002370 | | internal globus pallidus shell projection neuron (CL:0020004) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) (CL:4072022) | RO:0015004 | CLM:1000075 | | dual-feature fallopian tube progenitor cell (CL:4052070) | RO:0002162 | NCBITaxon:9606 | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | RO:0002162 | NCBITaxon:9606 | | acinar cell of salivary gland (CL:0002623) | RO:0002215 | GO:0017156 | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | subClassOf (rdfs:subClassOf) | L5 intratelencephalic projecting glutamatergic neuron (CL:4030064) | | centrilobular region hepatocyte (CL:0019029) | BFO:0000050 | UBERON:8400007 | | dual-feature fallopian tube progenitor cell (CL:4052070) | subClassOf (rdfs:subClassOf) | progenitor cell (CL:0011026) | | excretory duct cell of salivary gland (CL:4052069) | subClassOf (rdfs:subClassOf) | salivary gland glandular cell (CL:1001596) | | beam cell (CL:7770005) | subClassOf (rdfs:subClassOf) | trabecular meshwork cell (CL:0002367) | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | RO:0002162 | NCBITaxon:9606 | | lower motor neuron (CL:0008039) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | internal globus pallidus shell projection neuron (CL:0020004) | subClassOf (rdfs:subClassOf) | GABAergic neuron (CL:0000617) | | G8 retinal ganglion cell (CL:0003011) | RO:0002162 | NCBITaxon:9986 | | Bm1 B cell (CL:0000961) | RO:0002162 | NCBITaxon:9606 | | M6 retinal ganglion cell (CL:0003035) | RO:0002162 | NCBITaxon:10090 | | serous acinar cell of salivary gland (CL:4052065) | BFO:0000051 | GO:0042588 | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | subClassOf (rdfs:subClassOf) | VIP GABAergic interneuron (CL:4023016) | | trabecular meshwork cell (CL:0002367) | subClassOf (rdfs:subClassOf) | connective tissue cell (CL:0002320) | | Betz upper motor neuron (CL:4023052) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | internal globus pallidus core projecting neuron (CL:0020003) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | beam B cell, human (CL:7770006) | subClassOf (rdfs:subClassOf) | trabecular meshwork cell (CL:0002367) | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | RO:0002162 | NCBITaxon:9606 | | M9 retinal ganglion cell (CL:0003040) | RO:0002162 | NCBITaxon:10090 | | immature T cell (CL:0002420) | RO:0000053 | PATO:0001501 | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | subClassOf (rdfs:subClassOf) | L2/3 intratelencephalic projecting glutamatergic neuron (CL:4030059) | | M5 retinal ganglion cell (CL:0003034) | RO:0002162 | NCBITaxon:10090 | | juxtacanalicular tissue cell (CL:7770002) | RO:0002215 | GO:0070278 | | agouti-related protein expressing neuron (CL:4072017) | subClassOf (rdfs:subClassOf) | GABAergic neuron (CL:0000617) | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | RO:0002162 | NCBITaxon:9606 | | sst chodl GABAergic interneuron (Homo sapiens) (CL:4072031) | RO:0002162 | NCBITaxon:9606 | | acinar cell of salivary gland (CL:0002623) | RO:0002215 | GO:0046541 | | internal globus pallidus shell projection neuron (CL:0020004) | RO:0002292 | PR:000015665 | | nail matrix keratinocyte (CL:4052064) | subClassOf (rdfs:subClassOf) | epidermal keratinocyte (CL:4052061) | | serous acinar cell of salivary gland (CL:4052065) | BFO:0000050 | UBERON:0013232 | | pvalb GABAergic interneuron (Homo sapiens) (CL:4072029) | RO:0002162 | NCBITaxon:9606 | | keratinized cell of hair follicle (CL:0010000) | BFO:0000050 | UBERON:0005932 | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | RO:0002292 | PR:O76070 | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | RO:0002292 | PR:P01282 | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | RO:0002162 | NCBITaxon:9606 | | L2/3/5 fan Martinotti sst GABAergic interneuron (Mmus) (CL:4023030) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | mucosal-associated invariant T cell (CL:0000940) | RO:0002202 | double-positive, alpha-beta thymocyte (CL:0000809) | | mucous acinar cell of salivary gland (CL:4052066) | BFO:0000051 | GO:0098594 | | G2 retinal ganglion cell (CL:0003003) | RO:0002162 | NCBITaxon:9986 | | mature natural killer cell (CL:0000824) | RO:0000053 | PATO:0001701 | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | RO:0002162 | NCBITaxon:9606 | | midzonal region hepatocyte (CL:0019028) | BFO:0000050 | UBERON:8400008 |

</details>

<details> <summary>Nodes added to subset: 51</summary>

| Term | Subset | ----|----| | nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron (CL:4030051) | human_reference_atlas | | GABAergic neuron (CL:0000617) | human_reference_atlas | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | cellxgene_subset | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | BDS_subset | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | BDS_subset | | pvalb GABAergic interneuron (Homo sapiens) (CL:4072029) | cellxgene_subset | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | BDS_subset | | glutamatergic neuron of the basal ganglia (CL:4042040) | human_reference_atlas | | myocyte of middle internodal tract (CL:1000290) | human_reference_atlas | | lamp5 GABAergic interneuron (CL:4023011) | human_reference_atlas | | dopaminergic neuron (CL:0000700) | human_reference_atlas | | sst chodl GABAergic interneuron (CL:4023121) | human_reference_atlas | | striatal pthlh-expressing interneuron (CL:4042023) | human_reference_atlas | | central nervous system neuron (CL:2000029) | human_reference_atlas | | Island of Calleja granule cell (CL:4030053) | human_reference_atlas | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | cellxgene_subset | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | cellxgene_subset | | nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron (CL:4030052) | human_reference_atlas | | pvalb GABAergic interneuron (Homo sapiens) (CL:4072029) | BDS_subset | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | BDS_subset | | nodal myocyte (CL:0002072) | human_reference_atlas | | midbrain dopaminergic neuron (CL:2000097) | human_reference_atlas | | striosomal D1 medium spiny neuron (CL:4030048) | human_reference_atlas | | TAC3-positive striatal interneuron (CL:4042001) | human_reference_atlas | | RXFP1-positive interface island D1-medium spiny neuron (CL:4030054) | human_reference_atlas | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | cellxgene_subset | | substantia nigra dopaminergic neuron (CL:4042025) | human_reference_atlas | | Lamp5 Lhx6 neuron (CL:4042013) | human_reference_atlas | | cholinergic neuron (CL:0000108) | human_reference_atlas | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | cellxgene_subset | | striosomal D2 medium spiny neuron (CL:4030049) | human_reference_atlas | | lateral ganglionic eminence derived neuron (CL:4023035) | human_reference_atlas | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | cellxgene_subset | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | cellxgene_subset | | GABAergic interneuron (CL:0011005) | human_reference_atlas | | matrix D2 medium spiny neuron (CL:4030047) | human_reference_atlas | | VIP GABAergic interneuron (CL:4023016) | human_reference_atlas | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | cellxgene_subset | | matrix D1 medium spiny neuron (CL:4030043) | human_reference_atlas | | sst GABAergic interneuron (CL:4023017) | human_reference_atlas | | sst chodl GABAergic interneuron (Homo sapiens) (CL:4072031) | cellxgene_subset | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | BDS_subset | | myocyte of posterior internodal tract (CL:1000291) | human_reference_atlas | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | cellxgene_subset | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | BDS_subset | | D1/D2-hybrid medium spiny neuron (CL:4030050) | human_reference_atlas | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | BDS_subset | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | cellxgene_subset | | lamp5 GABAergic interneuron (Homo sapiens) (CL:4072034) | BDS_subset | | myocyte of anterior internodal tract (CL:1000287) | human_reference_atlas | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | cellxgene_subset |

</details>

<details> <summary>Classes added: 41</summary>

| Term | ----| | gut mesenchymal lymphoid tissue organizer cell (CL:0020000) | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | | PAX6 GABAergic interneuron (Homo sapiens) (CL:4072036) | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | | serous acinar cell of salivary gland (CL:4052065) | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | | suprabasal cell (CL:7770004) | | dual-feature fallopian tube progenitor cell (CL:4052070) | | juxtacanalicular tissue cell (CL:7770002) | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | | corticotropin-releasing neuron (CL:4072021) | | mucous acinar cell of salivary gland (CL:4052066) | | beam B cell, human (CL:7770006) | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | | excretory duct cell of salivary gland (CL:4052069) | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | | internal globus pallidus shell projection neuron (CL:0020004) | | seromucous acinar cell of salivary gland (CL:4052067) | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | | sst chodl GABAergic interneuron (Homo sapiens) (CL:4072031) | | beam cell (CL:7770005) | | internal globus pallidus core projecting neuron (CL:0020003) | | beam A cell (CL:7770003) | | NPY interneuron (CL:4072016) | | SCN pacemaker neuron (CL:4072019) | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | | V1delta gamma-delta T cell (CL:0020001) | | pacemaker neuron (CL:4072018) | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | | pvalb GABAergic interneuron (Homo sapiens) (CL:4072029) | | lamp5 GABAergic interneuron (Homo sapiens) (CL:4072034) | | nail bed keratinocyte (CL:4052063) | | agouti-related protein expressing neuron (CL:4072017) | | quiescent fibroblast (CL:4052071) | | Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) (CL:4072022) | | mucosal-associated invariant T cell, human (CL:0020002) | | nail matrix keratinocyte (CL:4052064) | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) |

</details>

<details> <summary>Synonyms added: 61</summary>

| Term | New Synonym | Predicate | ----|----|----| | quiescent fibroblast (CL:4052071) | inactive fibroblast | oio:hasExactSynonym | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | L5b neuron (Homo sapiens) | oio:hasRelatedSynonym | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | L5/6 NP (Homo sapiens) | oio:hasRelatedSynonym | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | L5 IT (Homo sapiens) | oio:hasRelatedSynonym | | V1delta gamma-delta T cell (CL:0020001) | Vδ1+ Gamma-Delta T cell | oio:hasRelatedSynonym | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | pyramidal tract (PT) neuron (Homo sapiens) | oio:hasNarrowSynonym | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | subcerebral projection (SCPN) neuron (Homo sapiens) | oio:hasBroadSynonym | | interna theca cell (CL:4052012) | androgenic theca cell | oio:hasRelatedSynonym | | circulating fibrocyte (CL:0000135) | monocyte-derived fibrocyte | oio:hasNarrowSynonym | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | L4 IT (Homo sapiens) | oio:hasRelatedSynonym | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | Pyramidal tract-like (PT-l) (Homo sapiens) | oio:hasExactSynonym | | mucosal-associated invariant T cell (CL:0000940) | mucosal-associated invariant T-lymphocyte | oio:hasExactSynonym | | dual-feature fallopian tube progenitor cell (CL:4052070) | non-ciliated secretory epithelial cell 2-1 (NCSE2-1 cells) | oio:hasNarrowSynonym | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | SST+ IN (Homo sapiens) | oio:hasRelatedSynonym | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | L6 IT Car3 neuron (Homo sapiens) | oio:hasRelatedSynonym | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | thick-tufted layer 5 (TTL5) pyramidal neuron (Homo sapiens) | oio:hasExactSynonym | | mucosal-associated invariant T cell, human (CL:0020002) | MAIT, human | oio:hasRelatedSynonym | | internal globus pallidus core projecting neuron (CL:0020003) | GPi core | oio:hasRelatedSynonym | | gut mesenchymal lymphoid tissue organizer cell (CL:0020000) | gut mLTo cell | oio:hasRelatedSynonym | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | VIP neuron (Homo sapiens) | oio:hasRelatedSynonym | | caudal ganglionic eminence derived interneuron (CL:4023064) | caudal ganglionic eminence derived GABAergic interneuron | oio:hasExactSynonym | | V1delta gamma-delta T cell (CL:0020001) | Vδ1+ γδ T Cell | oio:hasRelatedSynonym | | mucosal-associated invariant T cell (CL:0000940) | mucosal-associated invariant T lymphocyte | oio:hasExactSynonym | | NPY interneuron (CL:4072016) | NPY-expressing neocortical interneuron | oio:hasRelatedSynonym | | corticotropin-releasing neuron (CL:4072021) | CRF neuron | oio:hasRelatedSynonym | | externa theca cell (CL:4052013) | structural theca cell | oio:hasRelatedSynonym | | acinar cell of salivary gland (CL:0002623) | salivary gland acinar cell | oio:hasExactSynonym | | dual-feature fallopian tube progenitor cell (CL:4052070) | unclassified fallopian tube progenitor | oio:hasExactSynonym | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | L6 IT Car3 glutamatergic neuron (Homo sapiens) | oio:hasExactSynonym | | mucosal-associated invariant T cell, human (CL:0020002) | mucosal-associated invariant T-lymphocyte, human | oio:hasExactSynonym | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | Chandelier PV (Homo sapiens) | oio:hasExactSynonym | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | burst-firing layer 5 neuron (Homo sapiens) | oio:hasExactSynonym | | NPY interneuron (CL:4072016) | NPY-expressing neuron | oio:hasExactSynonym | | mucosal-associated invariant T cell (CL:0000940) | mucosal invariant T cell | oio:hasExactSynonym | | mucosal-associated invariant T cell, human (CL:0020002) | mucosal-associated invariant T lymphocyte, human | oio:hasExactSynonym | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | VIP-IN (Homo sapiens) | oio:hasRelatedSynonym | | juxtacanalicular tissue cell (CL:7770002) | JCT cell | oio:hasRelatedSynonym | | acinar cell of salivary gland (CL:0002623) | salivary acinar cell | oio:hasExactSynonym | | mucosal-associated invariant T cell (CL:0000940) | mucosal-associated invariant T-cell | oio:hasExactSynonym | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | L6-IT-Car3 cell (Homo sapiens) | oio:hasRelatedSynonym | | excretory duct cell of salivary gland (CL:4052069) | salivary excretory duct cell | oio:hasExactSynonym | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | L6 CT (Homo sapiens) | oio:hasExactSynonym | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | VIP type (Homo sapiens) | oio:hasRelatedSynonym | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | Vip (Homo sapiens) | oio:hasRelatedSynonym | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | L6 IT (Homo sapiens) | oio:hasRelatedSynonym | | mucosal-associated invariant T cell (CL:0000940) | MAIT | oio:hasRelatedSynonym | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | somatostatin-expressing inhibitory interneuron (Homo sapiens) | oio:hasRelatedSynonym | | mucosal-associated invariant T cell, human (CL:0020002) | mucosal-associated invariant T-cell, human | oio:hasExactSynonym | | interna theca cell (CL:4052012) | steroidogenic theca interna cell | oio:hasRelatedSynonym | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | SOM+ inhibitory interneuron (Homo sapiens) | oio:hasRelatedSynonym | | corticotropin-releasing neuron (CL:4072021) | CRH neuron | oio:hasRelatedSynonym | | nail matrix keratinocyte (CL:4052064) | nail matrix epithelial keratinocyte | oio:hasExactSynonym | | internal globus pallidus shell projection neuron (CL:0020004) | GPi shell | oio:hasRelatedSynonym | | dual-feature fallopian tube progenitor cell (CL:4052070) | non-ciliated secretory epithelial cell 2-2 (NCSE2-2 cells) | oio:hasNarrowSynonym | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | L6-IT-Car3 (Homo sapiens) | oio:hasRelatedSynonym | | VIP GABAergic interneuron (CL:4023016) | VIP neuron | oio:hasRelatedSynonym | | SCN pacemaker neuron (CL:4072019) | pacemaker neuron of the suprachiasmatic nucleus | oio:hasExactSynonym | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | L6 IT Car3 (Homo sapiens) | oio:hasRelatedSynonym | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | L2/3 IT (Homo sapiens) | oio:hasRelatedSynonym | | sst chodl GABAergic interneuron (Homo sapiens) (CL:4072031) | long-range GABAergic interneuron (Homo sapiens) | oio:hasBroadSynonym | | agouti-related protein expressing neuron (CL:4072017) | AgRP neuron | oio:hasRelatedSynonym |

</details>

<details> <summary>Text definitions added: 41</summary>

| Term | New Text Definition | ----|----| | nail bed keratinocyte (CL:4052063) | A keratinocyte that resides in the nail bed, responsible for tightly attaching the nail plate to the underlying dermis. Unlike typical epidermal keratinocytes, it exhibits limited proliferation, undergoes modified differentiation that skips the granular layer and conventional cornification, and primarily ensures adhesion and maintenance of the nail plate. In humans, this cell expresses characteristic markers, including the protease inhibitor SPINK6 and the differentiation-associated protein KRT16. | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | A transcriptomically distinct GABAergic neuron that expresses the vasoactive intestinal polypeptide and that has its soma located in the forebrain. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip. | | pvalb GABAergic interneuron (Homo sapiens) (CL:4072029) | A transcriptomically distinct GABAergic interneuron with a soma located in a cerebral cortex and it expresses Parvalbumin. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Pvalb. | | beam A cell (CL:7770003) | A beam cell within the eye's trabecular meshwork, molecularly distinguished by FABP4 expression in humans and spatially intermingled with Beam B cells throughout the uveal and corneoscleral meshwork regions. In mice, a transcriptionally analogous Beam A–like cluster (mC14) exists, sharing core TM markers (Myoc, Mgp, Pdpn, Chil1) and functional attributes. | | beam cell (CL:7770005) | A trabecular meshwork cell that is part of the eye's trabecular meshwork, residing in the uveal and corneoscleral meshwork regions and serving as the primary biological filter in the aqueous humor drainage cascade. This cell exhibits endothelial-like properties, including production of antithrombogenic substances such as tissue plasminogen activator, while also demonstrating phagocytic activity to remove cellular debris from aqueous humour before the fluid moves deeper into the less porous juxtacanalicular tissue. | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L6 IT. | | serous acinar cell of salivary gland (CL:4052065) | An acinar cell of the salivary gland, characterized by a pyramidal or triangular shape with a spherical nucleus and abundant eosinophilic zymogen granules. This cell secretes watery, enzyme‐rich fluid containing α-amylase, proline-rich proteins, and secretory immunoglobulins for starch digestion and antimicrobial defence. In humans and mice, serous acinar cell predominates in the parotid gland and to a lesser extent in the submandibular gland, where it exists alongside mucous acinar cells (Maruyama et al., 2019). | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found between cortical layer 2-4. This intratelencephalic-projecting glutamatergic neuron has thin-tufted apical dendrites and extends its axonal projection into L5 in the neocortex. This neuronal type has a hyperpolarised resting membrane potential. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L2/3 IT. | | NPY interneuron (CL:4072016) | An interneuron that expresses neuropeptide Y (NPY) and is mainly located in cortical layers II–III and VI, as well as in various brain regions such as the medial geniculate and inferior colliculus. The NPY cell population is physiologically diverse, displaying a range of firing behaviors, including adapting, fast-spiking, and accelerating patterns. | | V1delta gamma-delta T cell (CL:0020001) | A mature gamma-delta T Cell with T cell receptors consisting of the Vδ1 segment paired with various V gamma chains. This cell is enriched in the gut, skin (Davey et al., 2018) and the female reproductive tract (Wu et al., 2022). It exhibits potent cytotoxic capabilities through perforin/granzyme and death receptor pathways. | | L5/6 near-projecting glutamatergic neuron (Homo sapiens) (CL:4072042) | A transcriptomically defined near-projecting glutamatergic neuron with a soma found in cortical layer 5/6 in humans. | | lamp5 GABAergic interneuron (Homo sapiens) (CL:4072034) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Lamp5. | | beam B cell, human (CL:7770006) | A trabecular meshwork cell within the eye's trabecular meshwork. This cell is molecularly distinguished by TMEFF2 expression in humans. A beam B cell is spatially intermingled with beam A cells throughout the uveal and corneoscleral meshwork regions, but demonstrates a tendency to localise closer to the juxtacanalicular tissue. | | L6 corticothalamic-projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072044) | A transcriptomically distinct corticothalamic-projecting neuron with a soma found in cortical layer 6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons', Author Categories: 'CrossArea_subclass', clusters L6 CT. | | corticotropin-releasing neuron (CL:4072021) | A specialised type of interneuron defined by the secretion of corticotropin-releasing hormone (CRH), a key peptide in activating the hypothalamic–pituitary–adrenal (HPA) axis during stress. It is primarily located in the paraventricular nucleus (PVN) of the hypothalamus, with additional presence in the hippocampus, piriform area, central amygdalar nucleus, Barrington's nucleus, and inferior olivary complex (Peng et al., 2017). | | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sncg. | | quiescent fibroblast (CL:4052071) | A fibroblast in a quiescent state, characterized by a smaller, spindle-shaped morphology with a relatively small cytoplasm, modest rough endoplasmic reticulum and condensed chromatin. Despite low proliferation and contractility, it maintains high metabolic activity for extracellular-matrix homeostasis through continuous matrix protein turnover and mechanosensitive signaling. This cell can rapidly differentiate into contractile myofibroblasts under injury or inflammatory cues to drive tissue repair. | | excretory duct cell of salivary gland (CL:4052069) | A duct epithelial cell that is part of the excretory duct of the salivary gland, which transports saliva from the intralobular ductal system to the oral cavity. While primarily serving as a conduit, this cell may play a role in the saliva modification, contributing to its hypotonicity. In humans, this cell has a pseudostratified columnar shape. | | nail matrix keratinocyte (CL:4052064) | A keratinocyte that is part of the nail matrix epithelium, distinguished by its high proliferative capacity and its role in nail plate formation via onychokeratinization, a differentiation process that uniquely bypasses the formation of a granular layer, resulting in the production of hard, compact keratin. Unlike skin epidermal keratinocytes, this cell expresses a distinctive mix of hard (hair-type) and select epidermal keratins (Kitahara and Ogawa, 1993). In humans, LGR6 and WNT6 are enriched in the basal compartment, with LGR6 marking nail stem cells in both mice and humans, and exhibiting strong expression in the human proximal nail matrix (Kim et al., 2021). | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neuron', Author Categories: 'CrossArea_subclass', cluster L6b. | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | A transcriptomically definined chandelierl pvalb GABAergic interneuron in humans. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Chandelier. | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L5 IT. | | agouti-related protein expressing neuron (CL:4072017) | A GABAergic neuron located in the arcuate nucleus of the hypothalamus that expresses agouti-related protein (AgRP). This neuron can coexpress AgRP, GABA, and neuropeptide Y (NPY) in mice, and plays a key role in integrating metabolic signals. It is activated by hunger-related hormones such as ghrelin and inhibited by satiety signals like leptin. | | juxtacanalicular tissue cell (CL:7770002) | A trabecular meshwork cell of the juxtacanalicular tissue (JCT), characterized by a spindle-shaped, fibroblast-like morphology within a loose extracellular matrix immediately adjacent to Schlemm's canal. It expresses CHI3L1 (human and mouse) and ANGPTL7 (human), as well as smooth muscle actin for contractility. Unlike other trabecular meshwork cells, it does not form monolayers but exists in a loose network, regulating aqueous humor outflow resistance through continuous ECM remodelling, mechanotransduction, and formation of intracellular pores historically called giant vacuoles. | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst). The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Sst. | | seromucous acinar cell of salivary gland (CL:4052067) | An acinar cell of the salivary gland, with a hybrid seromucous phenotype, co-expressing serous and mucous markers and producing a mixed secretion of enzymes-containing serous fluid and mucins essential for lubrication, digestion, and antimicrobial defense. Predominant in the submandibular glands of humans and mice, its differentiation and secretory gene expression are regulated by FGFR2b–MAPK signaling, driven by paracrine FGF7 from adjacent myoepithelial cells, which provides a key niche signal for seromucous identity. | | SCN pacemaker neuron (CL:4072019) | A type of neuron located in the suprachiasmatic nucleus (SCN) that possesses intrinsic circadian rhythmicity, characterized by strong and rhythmic expression of core clock genes and the ability to independently generate and sustain circadian oscillations. In mice, the specific subtypes Avp+/Nms+, Vip+/Nms+, and Cck+/C1ql3+ neurons have the most robust circadian gene expression and contribute to synchronizing and maintaining rhythmicity within the SCN network (Wen et al., 2020). | | gut mesenchymal lymphoid tissue organizer cell (CL:0020000) | A mesenchymal stromal cell found in the gut during development, and interacts with lymphoid tissue inducer (LTi) cells to drive secondary lymphoid organ formation (Prados et al., 2021). It expresses LTβR, PDGFRα, and VCAM, and upon activation secretes chemokines(e.g. CXCL13) and cytokines to organise lymphoid tissue architecture and recruit immune cells in both mice and humans (Denton el al., 2019; Elmentaite et al., 2021). As a multipotent progenitor, an mLTo cell differentiates into adult stromal subsets, including fibroblastic reticular cells (FRCs) (Prados et al., 2021), and its descendants persist in the adult gut-associated lymphoid tissues to maintain immune homeostasis(Denton el al., 2019; Lütge et al., 2021). | | Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) (CL:4072022) | A Lamp5 Lhx6 GABAergic interneuron of Homo sapiens. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6 | | pacemaker neuron (CL:4072018) | A neuron that generates rhythmic bursts of action potentials independently of synaptic input. This intrinsic property enables it to maintain oscillatory activity even when isolated from other neurons. It populates the brainstem, hypothalamus, basal ganglia, spinal cord, and cerebellum. It plays a crucial role in regulating circadian rhythms in the suprachiasmatic nucleus, generating respiratory rhythms in the preBötzinger complex, and synchronizing neural networks. | | suprabasal cell (CL:7770004) | An epithelial cell that resides in the layer(s) immediately above the basal layer in stratified or pseudostratified epithelia. This cell mainly originates from basal cells and is found across various tissues, including skin, esophagus, oral mucosa, airway, and cornea. | | mucosal-associated invariant T cell, human (CL:0020002) | A mucosal-associated invariant T (MAIT) cell found in various tissues including human blood, liver, gut, and lung, characterised by a semi-invariant T cell receptor (TCR) comprising TRAV1-2 (Vα7.2) predominantly paired with TRAJ33, and high expression of CD161. Upon activation, MAIT cells produce inflammatory cytokines, including IFN-γ, TNF-α, and IL-17. | | dual-feature fallopian tube progenitor cell (CL:4052070) | A bipotent progenitor cell within the human fallopian tube epithelium, characterized by the concurrent expression of epithelial (e.g., EpCAM/CD326) and endothelial (e.g., PECAM1/CD31) markers at both the cell surface and transcript levels. This cell has the capacity to differentiate into ciliated and secretory epithelial cells, as well as potentially endothelial/stromal lineages. Positioned at the apex of lineage bifurcation, the cell exhibits stem-like and endothelial features, representing an intermediate developmental state between undifferentiated progenitors and lineage-committed epithelial cells. | | L6 intratelencephalic projecting Car3 glutamatergic neuron (Homo sapiens) (CL:4072040) | A transcriptomically distinct intratelencepalic-projecting glutamatergic neuron that expresses Car3 with a soma found in L6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_cluster', L6 IT Car3. | | internal globus pallidus core projecting neuron (CL:0020003) | A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi) of primates, in the central "core" region. It expresses parvalbumin, is primarily GABAergic, and projects to motor thalamic nuclei including the ventral anterior, ventrolateral, and ventromedial nuclei. This neuron corresponds to the sensorimotor output population of the GPi, as demonstrated in human tissue and cross-species comparative studies (Wallace et al., 2017) and by classic tracing in primates (Parent & De Bellefeuille, 1982; Parent et al., 2001). | | L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) (CL:4072043) | A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET. | | internal globus pallidus shell projection neuron (CL:0020004) | A projection neuron that has its soma located in the internal segment of the globus pallidus (GPi), in the peripheral 'shell' region. In mice and primates, it expresses somatostatin and shows dual expression of GABAergic and glutamatergic markers, enabling co-release of GABA and glutamate (Wallace et al., 2017). It projects primarily to the lateral habenula (Parent & De Bellefeuille, 1982; Wallace et al., 2017), forming the limbic/aversive output stream of the GPi. | | PAX6 GABAergic interneuron (Homo sapiens) (CL:4072036) | A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses the transcript PAX6. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters PAX | | sst chodl GABAergic interneuron (Homo sapiens) (CL:4072031) | A transcriptomically distinct sst GABAergic interneuron that also expresses Chodl. These neurons are rare and correspond to the only known interneurons with long-range projection. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: MGE-derived interneurons', Author Categories: 'CrossArea_subclass', clusters Sst Chodl. | | L4 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072039) | A transcriptomically distinct intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3-4. This neuron type can have a pyramidal, star-pyramidal or spiny stellate morphology and projects its output to L2/3 and L5A/B. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: IT-projecting excitatory neurons', Author Categories: 'CrossArea_subclass', L4 IT. | | mucous acinar cell of salivary gland (CL:4052066) | An acinar cell of the salivary gland, responsible for producing a viscous, mucin‐rich solution, thereby facilitating lubrication and protection of the oral mucosa. This cell is characterized by an elongated shape, clear cytoplasm filled with mucin granules, and a basally compressed nucleus (Barrows et al., 2020). In humans and mice, the mucous acinar cell predominates in the sublingual gland and minor salivary glands, while also being present in mixed glands such as the submandibular gland, where it coexists with serous acinar cells (Maruyama et al., 2019). |

</details>

<details> <summary>Relationships removed: 33</summary>

| Subject| Predicate| Object| ----|----|----| | optic choroid fibroblast (CL:2000070) | subClassOf (rdfs:subClassOf) | fibroblast (CL:0000057) | | olfactory bulb tufted cell (CL:1001503) | subClassOf (rdfs:subClassOf) | neuron of the forebrain (CL:0012001) | | squamous cell of epidermis (CL:0002190) | subClassOf (rdfs:subClassOf) | keratinocyte (CL:0000312) | | interneuron (CL:0000099) | RO:0002215 | GO:0014051 | | nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron (CL:4030051) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | RXFP1-positive interface island D1-medium spiny neuron (CL:4030054) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | T follicular helper cell (CL:0002038) | RO:0002215 | GO:0051024 | | choroidal cell of the eye (CL:0000348) | subClassOf (rdfs:subClassOf) | obsolete structural cell (CL:0000293) | | Bm1 B cell (CL:0000961) | subClassOf (rdfs:subClassOf) | fraction F mature B cell (CL:0002056) | | somatomotor neuron (CL:0005024) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | mesenchymal cell (CL:0008019) | subClassOf (rdfs:subClassOf) | eukaryotic cell (CL:0000255) | | midzonal region hepatocyte (CL:0019028) | BFO:0000050 | UBERON:8400007 | | medium spiny neuron (CL:1001474) | subClassOf (rdfs:subClassOf) | central nervous system neuron (CL:2000029) | | myocardial endocrine cell of septal division of left branch of atrioventricular bundle (CL:1000375) | subClassOf (rdfs:subClassOf) | His-Purkinje system cell (CL:0010007) | | direct pathway medium spiny neuron (CL:4023026) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | branchiomotor neuron (CL:0005023) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | tendon cell (CL:0000388) | subClassOf (rdfs:subClassOf) | circulating fibrocyte (CL:0000135) | | centrilobular region hepatocyte (CL:0019029) | BFO:0000050 | UBERON:8400008 | | D1/D2-hybrid medium spiny neuron (CL:4030050) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | trabecular meshwork cell (CL:0002367) | subClassOf (rdfs:subClassOf) | endothelial cell (CL:0000115) | | neuromast hair cell (CL:0000856) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | Lamp5 Lhx6 neuron (CL:4042013) | RO:0015004 | CLM:1000075 | | olfactory bulb interneuron (CL:1001434) | subClassOf (rdfs:subClassOf) | neuron of the forebrain (CL:0012001) | | cerebral cortex neuron (CL:0010012) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | indirect pathway medium spiny neuron (CL:4023029) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | scleral cell (CL:0000347) | subClassOf (rdfs:subClassOf) | obsolete structural cell (CL:0000293) | | optic choroid fibroblast (CL:2000070) | BFO:0000050 | UBERON:0001776 | | keratinized cell of hair follicle (CL:0010000) | BFO:0000050 | UBERON:0005933 | | circulating fibrocyte (CL:0000135) | RO:0002202 | fibroblast (CL:0000057) | | nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron (CL:4030052) | subClassOf (rdfs:subClassOf) | BFO:0000002 | | otic fibrocyte (CL:0002665) | subClassOf (rdfs:subClassOf) | circulating fibrocyte (CL:0000135) | | obsolete structural cell (CL:0000293) | subClassOf (rdfs:subClassOf) | cell (CL:0000000) | | mature NK T cell (CL:0000814) | RO:0002202 | immature NK T cell stage IV, mouse (CL:0002042) |

</details>

<details> <summary>Nodes obsoleted without replacement: 1</summary>

| Term | ----| | obsolete structural cell (CL:0000293) |

</details>

<details> <summary>Mappings removed: 1</summary>

| Subject | Predicate | Object | ----|----|----| | obsolete structural cell (CL:0000293) | oio:hasDbXref | ZFA:0005745 |

</details>

<details> <summary>Mappings added: 10</summary>

| Subject | Predicate | Object | ----|----|----| | sncg GABAergic interneuron (Homo sapiens) (CL:4072035) | oio:hasDbXref | ILX:0770150 | | L6 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072041) | oio:hasDbXref | ILX:0770158 | | Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) (CL:4072022) | oio:hasDbXref | https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/ | | L5 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072038) | oio:hasDbXref | ILX:0770157 | | L6b glutamatergic cortical neuron (Homo sapiens) (CL:4072045) | oio:hasDbXref | ILX:0770163 | | lamp5 GABAergic interneuron (Homo sapiens) (CL:4072034) | oio:hasDbXref | ILX:0770149 | | L2/3 intratelencephalic projecting glutamatergic neuron (Homo sapiens) (CL:4072037) | oio:hasDbXref | ILX:0770156 | | sst GABAergic interneuron (Homo sapiens) (CL:4072027) | oio:hasDbXref | ILX:0770152 | | VIP GABAergic interneuron (Homo sapiens) (CL:4072032) | oio:hasDbXref | ILX:0770151 | | chandelier pvalb GABAergic interneuron (Homo sapiens) (CL:4072046) | oio:hasDbXref | ILX:0107356 |

</details>

<details> <summary>Synonyms removed: 4</summary>

| Term | Removed Synonym | ----|----| | VIP GABAergic interneuron (CL:4023016) | cortical VIP neuron | | caudal ganglionic eminence derived interneuron (CL:4023064) | caudal ganglionic eminence derived GABAergic cortical interneuron | | medial ganglionic eminence derived GABAergic interneuron (CL:4023069) | MGE cortical interneuron | | caudal ganglionic eminence derived interneuron (CL:4023064) | CGE cortical interneuron |

</details>

<details> <summary>Nodes removed from subset: 1</summary>

| Term | Subset | ----|----| | immature NK T cell stage IV, mouse (CL:0002042) | human_reference_atlas |

</details>

CL Links to External Ontologies

<details> <summary>UBERON → CL (count: 1393)</summary>

</details>

<details> <summary>GO → CL (count: 2104)</summary>

</details>

<details> <summary>MONDO → CL (count: 184)</summary>

</details>

Click here for a complete current summary release report

What's Changed

• Fix spelling typo: dendtritic → dendritic in CL:4047054 by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3207
• updated the CL release documentation by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3221
• Add nail matrix keratinocyte (CL_4052062) cell type to Cell Ontology by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3203
• Fixed #3191 Added Term for SCN pacemaker neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3192
• #2455 Created Term for NPY interneuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3170
• Add nail bed keratinocyte cell type (CL:4033100) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3204
• obsoleted structural cell by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3225
• Fixed #3180 Added Corticotropin-releasing neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3193
• Revised acinar cell of salivary gland by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3227
• Fixes #3229 NTR seromucous acinar cell of salivary gland by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3230
• Fixes #3235 NTR-excretory duct cell of salivary gland by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3240
• Added serous acinar cell and mucous acinar cell (of salivary gland) by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3228
• Cajal-Retzius cell by @JABelfiore in https://github.com/obophenotype/cell-ontology/pull/3150
• #3233 FIXED axiomatisation of L6 Car3 interneuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3234
• #3173 added new term for Pacemaker neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3174
• #2444 Created term for AgRP neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3171
• Fixes #3196 NTR-dual-feature fallopian tube progenitor cell by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3248
• Fixes #3239 - Reclassify tendon cell and otic fibrocyte by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3245
• Add cross-ontology link tables (HP/GO/MONDO/UBERON → CL) to release pipeline by @ubyndr in https://github.com/obophenotype/cell-ontology/pull/3254
• Add thymus Uberon annotation to thymic plasmacytoid dendritic cell (CL_0000942) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3273
• Add Uberon annotation to small intestine serosal dendritic cell (CL_0002466) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3274
• Fixes #3243 fibrocyte (textual and logical def) by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3251
• Add logical definition linking squamous cell of epidermis to epidermis location by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3262
• Fixes #3252 NTR- quiescent fibroblast by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3253
• Add mouse taxon constraints to Gr1-positive monocyte cell types by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3281
• Add missing PMID references to Schlemm's canal endothelial cell definition by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3297
• Fix reference to deprecated GO class. by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3309
• Add cl-full to CL sparql QC checking by @matentzn in https://github.com/obophenotype/cell-ontology/pull/3308
• Fixes #3247 add species specific for pval GABA neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3249
• Add beam cell term (CL_7770005) to Cell Ontology by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3319
• #3287 Created human specific term for sst chodl by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3298
• Update suprabasal keratinocyte definition with comprehensive functional description and complete references by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3261
• Update CL_0010000 keratinized cell of hair follicle definition and location by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3263
• Fixes #3289 Created human specific term for Vip by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3301
• Add taxon constraints to distinguish mouse and human plasmacytoid dendritic cells by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3304
• Add mouse taxon constraints to Vgamma1.1/Vdelta6.3 thymocyte terms by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3299
• Fixes #3290 Created term for human lamp5 by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3303
• Fix hepatocyte location mappings for midzonal and centrilobular regions by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3277
• Fixes #3291 Create human term for sncg neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3307
• Add juxtacanalicular tissue cell (CL_7770002) - new trabecular meshwork cell subtype by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3279
• Fixes #3292 Create human specific term for Pax6 interneuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3310
• [Text and logical def] Connective tissue cell and Trabecular meshwork cell by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3278
• Fixes #3294 Created human term for L5 IT neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3312
• Add Beam A cell term (CL_7770003) to Cell Ontology by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3280
• Add EquivalentTo axiom for mature natural killer cell (CL:0000824) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3300
• Fixes #3295 Created term for human L4 IT by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3313
• Fixes #3293 Created human term for L2/3 interneuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3311
• FIXES #3242 sst GABAergic neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3244
• FIXES #3316 Create human term for L6 IT neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3317
• Add suprabasal cell term (CL_7770004) and update hierarchy for existing suprabasal terms by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3306
• Dont relabel imported annotation properties by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3333
• Support temporary IDs. by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3334
• Fixes 3238 copilot setup by @aleixpuigb in https://github.com/obophenotype/cell-ontology/pull/3241
• #3325 Created human term for L6 corticothalamic neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3330
• Add beam B cell, human (CL_7770006) - New term request by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3327
• #3324 Created human term for L5 et glut neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3329
• Update enterocyte of epithelium of large intestine definition and add literature references by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3342
• Add taxon constraints to retinal ganglion cells (RGCs) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3338
• Add mouse taxon constraints to Hardy fraction B cell classification terms by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3339
• Test: Move an axiom out of place. by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3367
• Test: Move an axiom out of place (2). by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3368
• Test: Move an axiom out of place (3). by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3369
• Test: Move an axiom out of place (4). by @gouttegd in https://github.com/obophenotype/cell-ontology/pull/3370
• FIXES #3314 Created human term for L6 car3 neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3315
• #3323 Created human term for L5/6 near projecting neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3328
• #3326 Created human term for L6b glut neuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3331
• Remove 'cortical' from rdfs:label and definitions for specified CL terms by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3357
• Add human-specific taxon constraints to Bm-classified B cell terms by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3340
• Add gut mesenchymal lymphoid tissue organizer cell (mLTo cell) [NTR] by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3343
• Add PMID:29924991 reference to CL_0008060 (GABA-Glut neuron) definition by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3362
• Fixes #3353 Created specific human term for chandelier pvalb gabaergic interneuron by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3354
• Remove 'cortical' from MGE and CGE GABAergic interneuron labels, definitions, comments, and synonyms by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3359
• Add related synonyms to externa and interna theca cells (PMID:36599970) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3371
• Add mouse taxon constraints to immature NKT stage terms (I–IV) by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3341
• Add V1delta gamma-delta T cell (CL_9900001) - NTR Issue #3065 by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3355
• Add human-specific MAIT cell term and rename CL_0000940 to "mucosal-associated invariant T cell" by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3372
• Adding approved CellGuide defs by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3378
• Add new term CL_9900000: internal globus pallidus core projecting neuron by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3364
• Add new term CL_9900001: internal globus pallidus shell projection neuron by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3366
• Add developmental lineage information to medium spiny neuron with supporting evidence by @Copilot in https://github.com/obophenotype/cell-ontology/pull/3352
• #3182 Lamp5 Lhx6 interneuron for species (general term, human, mouse) by @RiveraAndrea83 in https://github.com/obophenotype/cell-ontology/pull/3220
• refresh-imports-October25 for CL release by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3383
• 20251016-release (CL release) by @Caroline-99 in https://github.com/obophenotype/cell-ontology/pull/3387

Full Changelog: https://github.com/obophenotype/cell-ontology/compare/v2025-07-30...v2025-10-16