SYNTHESIS AND CHARACTERIZATION OF TRANSITION METAL COMPLEXES WITH BIOLOGICALLY ACTIVE LIGANDS
Description
Maqolada biologik faol ligandlar bilan o‘tish metallari komplekslarini sintez qilish va ularning tuzilishini o‘rganish masalalari tahlil qilingan. Tadqiqotda Cu(II), Ni(II) va Co(II) kabi metall ionlarining barqaror koordinatsion birikmalar hosil qilishdagi o‘rni hamda ularning biologik faollikka ta’siri yoritilgan. Spektroskopik (UV-Vis, IR, NMR, XRD, EPR) va analitik metodlar asosida metall-komplekslarning tuzilmasi hamda bog‘lanish tabiatini aniqlash usullari bayon etilgan. Sintez qilingan komplekslarning fizik-kimyoviy xususiyatlari — eruvchanlik, oksidlanish-qaytarilish potensiali va barqarorlik — ularning biologik faoliyati va farmakologik qo‘llanilish imkoniyatlari bilan uzviy bog‘liqligi asoslab berilgan. Tadqiqot natijalari metall asosli yangi dori vositalari va biokatalizatorlarni ishlab chiqishda ilmiy asos yaratadi.
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References
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