ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND PREMATURE OVARIAN AGING: A CROSS-SECTIONAL STUDY

Published October 14, 2025 | Version v1

Journal article Open

1. Republican specialized scientific and practical medical center for maternal and child health.

Vitamin D deficiency has been increasingly linked to ovarian dysfunction and

premature ovarian aging (POA). This study aims to assess the relationship between serum

vitamin D levels and ovarian reserve markers among reproductive-age women. A total of 140

women aged 22–38 years were evaluated for serum 25(OH)D, AMH, FSH, and estradiol levels.

Vitamin D deficiency (<20 ng/mL) was significantly associated with lower AMH and higher

FSH, suggesting that vitamin D insufficiency may accelerate ovarian aging through endocrine

and oxidative mechanisms.

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