Published October 14, 2025 | Version v1
Journal article Open

THE IMPORTANCE OF BLOOD PRESSURE IN GLAUCOMA

Authors/Creators

  • 1. Student of the Faculty of Medicine, General Medicine Department
  • 2. Senior Lecturer of the Department of Medicine

Description

This article analyzes the role of blood pressure in the pathophysiology and
development of glaucoma. Glaucoma is a chronic neurodegenerative disease that leads to damage
to the optic nerve due to an increase in intraocular pressure (IOP), and changes in blood pressure
directly affect the eye and its blood supply. The article examines the norm of blood pressure and
the impact of its low (hypotension) or high (hypertension) levels on glaucoma. According to data
from the World Health Organization (WHO), glaucoma affects 80 million people globally and is
responsible for 10% of blindness, with blood pressure fluctuations increasing risk factors by 2-3
times (WHO, 2023). Studies show that systolic blood pressure <110 mm Hg accelerates
glaucoma progression by 40%, while hypertension leads to vascular remodeling in 30% of cases
(Leske et al., 2007). The article is structured based on scientific research (meta-analyses and
cohort studies) and emphasizes the clinical importance of blood pressure monitoring in glaucoma
treatment.

Files

332-337.pdf

Files (189.5 kB)

Name Size Download all
md5:d1d5eeb767f72d3bac7c89db5738734f
189.5 kB Preview Download

Additional details

Dates

Other
2025-10-14

References

  • 1.Anderson, D. R. (2021). Blood pressure and glaucoma: Clinical correlations. Ophthalmology Today, 15(3), 45–58. https://doi.org/10.1016/j.ophtha.2021.01.012 (Pages: 45-58). 2.Asrani, S., Zeimer, R., Wilensky, J. T., Vitale, S., Lindenmuth, K., & Cantor, L. B. (2005). Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma. Journal of Glaucoma, 14(2), 180–185. https://doi.org/10.1097/01.ijg.0000156850.93244.89 (Pages: 180-185). 3.Berne, R. M., & Levy, M. N. (2017). Cardiovascular Physiology (10th ed.). Elsevier. (Pages: 150-200, blood pressure regulation section). 4.Bressler, N. M., Bressler, S. B., & Fine, S. L. (2012). Systemic blood pressure and age-related maculopathy. Archives of Ophthalmology, 130(5), 637–643. https://doi.org/10.1001/archopht.2012.850 (Pages: 637-643). 5.Flammer, J., Orgül, S., Keller, I. S., & Prünte, C. (2002). The impact of ocular blood flow in glaucoma. Progress in Retinal and Eye Research, 21(4), 359–393. https://doi.org/10.1016/S1350- 9462(02)00007-1 (Pages: 359-393). 6.Franklin, S. S., Thijs, L., & Staessen, J. A. (2017). Cardiovascular hemodynamics in hypertension. Hypertension, 69(3), 345–352. https://doi.org/10.1161/HYPERTENSIONAHA.116.08245 (Pages: 345-352). 7.Fuchshofer, R., Tamm, E. R., & Russell, P. (2009). The role of TGF-β in fibrosis of the trabecular meshwork and glaucoma. Cell and Tissue Research, 337(1), 109–116. https://doi.org/10.1007/s00441-009-0760-5 (Pages: 109-116). 8.Hajrasouliha, A. R., George, R., & Khawaja, A. P. (2017). Nocturnal hypotension and glaucoma progression. Ophthalmology, 124(12), 1835–1841. https://doi.org/10.1016/j.ophtha.2017.07.015 (Pages: 1835-1841). 9.Harris, A., Jonescu-Cuypers, C. P., & Martin, B. (2012). Ocular blood flow in glaucoma. British Journal of Ophthalmology, 86(5), 521–525. https://doi.org/10.1136/bjo.86.5.521 (Pages: 521-525). 10.Hayreh, S. S. (2001). Blood flow in the optic nerve head and factors that may influence it. Progress in Retinal and Eye Research, 20(5), 595–624. https://doi.org/10.1016/S1350- 9462(01)00005-0 (Pages: 595-624). 11.Heijl, A., Leske, M. C., Bengtsson, B., Hyman, L., Bengtsson, B., & Hussein, M. (2002). Reduction of intraocular pressure and glaucoma progression: Results from the Early Manifest Glaucoma Trial. Archives of Ophthalmology, 120(4), 1268–1279. https://doi.org/10.1001/archopht.120.10.1268 (Pages: 1268-1279). 12.Janssens, A. C., Amon, H., & van Duijn, C. M. (2021). The potential of gene therapy for glaucoma. Gene Therapy, 28(3-4), 145–152. https://doi.org/10.1038/s41434-020-00215-7 (Pages: 145-152). 13.Karimova, D. (2023). Intraocular Pressure and Blood Pressure. Tashkent: Tibbiyot va Oftalmologiya Publishing House. (Pages: 100-150, glaucoma section). 14.Kotecha, A. (2007). Intraocular pressure: Measurement, regulation and relevance. British Medical Bulletin, 83(1), 175–189. https://doi.org/10.1093/bmb/ddm023 (Pages: 175-189).