Published October 13, 2025 | Version v1

GIPOKINEZIYA SHAROITIDA YOG`LI DIETA BILAN NAYJK MODELINI YARATISH

  • 1. Andijon Davlat Tibbiyot Institut

Description

Ushbu eksperimental tadqiqotda yuqori yog‘li dieta  bilan oziqlantirilgan oq kalamushlar modeli orqali jigar to‘qimalarida yuzaga keladigan gistostrukturaviy o‘zgarishlar o‘rganildi. Gistostrukturaviy o‘zgarishlar  noalkogolli yog‘li jigar kasalligi bosqichlar  yuzaga keladigan steatoz (jigar parenximasini yog` bosishi), yallig‘lanish va fibrozlanishni   turli rivojlanish elementlari bilan mos tushadi[1,2,3]. Ushbu ma’lumotlar  Noalkogolli yog‘li jigar kasalligi (NAYJK)  rivojlanish mexanizmini eksperimental sharoitda baholash imkonini beradi va klinik-morfologik bog‘liqlikni ko`rsatadi[4-5].

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References

  • 1.1. Chalasani et al. N. et al. (2018). The diagnosis and management of non‐alcoholic fatty liver disease. Hepatology, 67, 328–357. 2.2. Younossi et al. Z.M. et al. (2016). Global epidemiology of NAFLD. Hepatology, 64, 73–84. 3.3. Ibrahim et al. S.H. et al. (2018). Animal models of NASH. Digestive Diseases and Sciences, 63(5), 1149–1161. 4.4. Machado and Diehl M.V., Diehl A.M. (2016). Pathogenesis of NASH. Gastroenterology, 150(8), 1769–1777. 5.5. Kucera and Cervinkova O., Cervinkova Z. (2014). Experimental models of NAFLD in rats. World J Gastroenterol, , 8364–8376. 6.6. Wang et al. X. et al. (2020). Effects of high-fat diet on liver injury. Sci Rep, 10, 17477. 7.7. Hebbard and George L., George J. (2011). Animal models of NAFLD. Nat Rev Gastroenterol Hepatol, 8, 35–44. 8.8. Takahashi et al. Y. et al. (2012). Animal models of NAFLD/NASH. World J Gastroenterol, 2300–2308. 9.9. Kleiner et al. D.E. et al. (2005). Histological scoring system for NAFLD. Hepatology, 41, 1313–1321. 10.10. Friedman et al. S.L. et al. (2018). Mechanisms of NAFLD and therapy. Nat Med, 24, 908–922.