Published October 10, 2025 | Version v1

Squamous cell carcinoma of the gallbladder. A case report

Description

Background: Gallbladder cancer accounts for a total of 1% of cancers in the world, Globocan mentions an incidence of 115000 [Figure 1], new cases per year, with a mortality of 0.8% of all cancers in the world. Its histological lineage adenocarcinoma and epidermoid encompass more than 95% of the histological lineage, however squamous cell carcinoma is a rare entity, there is still not enough scientific evidence of the incidence, it is estimated 1-3% of the subtypes of gallbladder cancer, and it is secondary keratin beads that present a predominant keratinization, with probable malignant glandular transformation. Diagnosis is a challenge, risk factors must be considered, TNM staging, and finally surgical management is the only curative treatment and the cost of radical or extended cholecystectomy, associated with chemotherapy and radiotherapy. Survival and follow-up in these patients are important. In this case we are dealing with a 48-year-old patient with a post-surgical diagnosis of squamous cell carcinoma of the gallbladder, a rare and poorly reported entity.

Keywords: Gallbladder cancer.

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