Published October 9, 2025
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Triplet Immunologic Modulation and Myelin Repair — A CCR5 / PD-L1 / Oligodendrocyte Axis for Neuro-Immune Regeneration
Authors/Creators
Notes
Disclaimer: This manuscript presents a conceptual framework and hypothesis-driven rationale. It is not intended to represent completed experimental validation. The ideas described here are meant to guide preclinical study design, and all mechanistic predictions require formal testing in controlled laboratory models.
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Additional details
Identifiers
- DOI
- 10.5281/zenodo.17290045 — Integrated Triplet Immunotherapy for Functional HIV Cure (parent concept).
- DOI
- 10.5281/zenodo.17290152 — Triplet Immunologic Modulation in Oncology — NF-κB / IL-1Ra Axis.
- DOI
- 10.5281/zenodo.17291133 — HIV Cure Pathways — Functional-Cure Framework Summary.
- DOI
- 10.17605/OSF.IO/9KCWP — CCR5 Antagonists & Triplet Immunotherapy Synergy in HIV (dataset & meta-analysis).
- Other
- FireGate Biotech R&D Index: https://firegatebiotech.com/fgd-research (organizational link; not a DOI but counts as a persistent reference).
Dates
- Submitted
-
2025-10-08
Software
- Repository URL
- https://firegatebiotech.com/fgd-research#
References
- 1. Rizzo, D. (2025). Integrated Triplet Immunotherapy for Functional HIV Cure: CCR5 Blockade, PD-L1 Inhibition, and Broadly Neutralizing Antibodies. DOI: 10.5281/zenodo.17290045 Relation type: Is derived from (parent conceptual framework)
- 2. Rizzo, D. (2025). Triplet Immunologic Modulation in Oncology — NF-κB / IL-1Ra Axis and CCR5-Mediated Cold-to-Hot Conversion. DOI: 10.5281/zenodo.17290152 Relation type: Is supplemented by (oncology expansion study)
- 3. Rizzo, D. (2025). HIV Cure Pathways — Research Share: Functional-Cure Framework Summary. DOI: 10.5281/zenodo.17291133 Relation type: Is part of (FireGate triplet immunology portfolio)
- 4. Rizzo, D. (2025). CCR5 Antagonists & Triplet Immunotherapy Synergy in HIV: Meta-Analysis and Dataset. DOI: 10.17605/OSF.IO/9KCWP Relation type: Is data source for (computational model cross-reference)
- 5. FireGate Biotech LLC (2025). FireGate Division of Research — Publications & Datasets. URL: https://firegatebiotech.com/fgd-research Relation type: Is referenced by (organizational research port
- 6. NIH Case Reference: CS1137565 — Compliance Information System record (acknowledged in disclosures) Relation type: Is documented under