Published September 23, 2025 | Version v1
Publication Open

Depth-resolved fiber photometry of amyloid plaque signals in freely behaving Alzheimer's disease mice

  • 1. ROR icon University of Strathclyde
  • 2. University of Strathclyde Department of Department of Physics
  • 3. Università di Padova
  • 4. Istituto Italiano di Tecnologia
  • 5. Italian Institute of Technology
  • 6. ROR icon Center for Biomolecular Nanotechnologies
  • 7. OptogeniX s.r.l.
  • 8. EDMO icon Danmarks Tekniske Universitetet

Description

This work was supported by the Medical Research Council (Grant Nos. MR/V033964/1 and MR/Y004051/1 to S.S.), the Alzheimer’s Research UK (Grant Nos. PPG2023B-019 to S.S.), the European Union’s Horizon 2020 (Grant Nos. H2020-ICT, DEEPER, 101016787 to N.M., Fi.P., M.P., K.M., M.D.V., Fe.P. and S.S.; MINING, 101125498 to M.D.V. and Fe.P.), the European Union’s Horizon Europe (Grant No. ERC, NEUROLIDAR, 101163003 to Fi.P.), and the PARD 2024 from the University of Padua to Fi.P. K.M. was supported through an RAEng Chair in Emerging Technologies. C.M., M.D.V., and Fe.P. acknowledge funding from the Project “RAISE (Robotics and AI for Socio-economic Empowerment) (code ECS00000035) funded by the European Union – NextGenerationEU PNRR MUR – M4C2 – Investimento 1.5 – Avviso ‘Ecosistemi dell’Innovazione” CUP J33C22001220001. Concerning ERC funding, views and opinions expressed are, however, those of the authors only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. The preprint has been posted to bioRxiv ( https://doi.org/10.1101/2025.04.08.647900).

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Additional details

Funding

European Commission
DEEPER - DEEP BRAIN PHOTONIC TOOLS FOR CELL-TYPE SPECIFIC TARGETING OF NEURAL DISEASES 101016787
European Commission
MINING - Multifunctional nano-bio INterfaces wIth deep braiN reGions 101125498
European Commission
NEUROLIDAR - measuriNg nEURal dynamics with label-free OpticaL multI-DomAin Recordings 101163003