Published October 8, 2025 | Version v1

PHARMACOLOGICAL MANAGEMENT OF IRON DEFECIENCY ANEMIA

Description

The most prevalent nutritional condition in the world is iron deficiency anemia (IDA), which is caused by insufficient iron intake, absorption, or chronic loss and impairs hemoglobin synthesis. Fatigue, pallor, dyspnea, and laboratory evidence of microcytic hypochromic anemia with low serum ferritin and transferrin saturation are some of the clinical manifestations. Parenteral iron is only used in cases of severe anemia, intolerance, or malabsorption; oral iron supplements, such as ferrous sulfate, are the first-line treatment. Monitoring hemoglobin and iron indices is crucial to determine response, and adjunctive therapy with folic acid or vitamin B12 may be required in cases of coexisting deficiencies. Improved tolerability and bioavailability are provided by novel formulations such as liposomal and sucrosomial iron, which emphasize customized treatment to replenish iron stores and enhance patient.

Files

DOC-20251008-WA0005..pdf

Files (247.0 kB)

Name Size Download all
md5:96efb50785e2f8a57da2f60bc1c21253
247.0 kB Preview Download

Additional details

Identifiers

Other
Osh State University

Dates

Accepted
2025-10-08
Accepted

References

  • 1. Jimenez, K., Kulnigg-Dabsch, S. & Gasche, C., 2015. Management of iron deficiency anemia. Gastroenterology & Hepatology (New York), 11(4), pp.241–250. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4836595/.
  • 2. National Institutes of Health, 2017. Iron Deficiency Anemia. In: Iron Deficiency Anemia: A Guide for the Primary Care Physician. Available at: https://www.ncbi.nlm.nih.gov/books/NBK448065/.
  • 3. Jiménez, K., Kulnigg-Dabsch, S. & Gasche, C., 2015. Management of iron deficiency anemia. Gastroenterology & Hepatology (New York), 11(4), pp.241–250. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4836595/.
  • 4. Pantopoulos, K., 2024. Oral iron supplementation: new formulations, old questions. Haematologica, 109(9), pp.2790–2801. Available at: https://doi.org/10.3324/haematol.2024.284967.
  • 5. Kolarš, B., Mijatović Jovin, V., Živanović, N., Minaković, I., Gvozdenović, N., Dickov Kokeza, I. & Lesjak, M., 2025. Iron deficiency and iron deficiency anemia: A comprehensive overview of established and emerging concepts. Pharmaceuticals, 18(8), 1104. Available at: https://www.mdpi.com/1424-8247/18/8/1104.
  • 6. Kolarš, B., Mijatović Jovin, V., Živanović, N., Minaković, I., Gvozdenović, N., Dickov Kokeza, I. & Lesjak, M., 2025. Iron deficiency and iron deficiency anemia: A comprehensive overview of established and emerging concepts. Pharmaceuticals, 18(8), p.1104. Available at: https://doi.org/10.3390/ph18081104.