Published October 6, 2025 | Version v1
Publication Open

BOLD fMRI at 9.4T with 3D stack-of-spirals readouts

Authors/Creators

  • 1. Maastricht Brain Imaging Centre, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
  • 2. Scannexus BV, Maastricht, The Netherlands
  • 3. University Paris-Saclay, CEA, CNRS, BAOBAB, NeuroSpin, Gif-sur-Yvette, France

Description

In this work we investigate the use of spiral readouts for sub-millimeter BOLD fMRI at 9.4T, and verify simulations of the BOLD PSF with functional experiments. We confirm that a TE < T2* can be employed for spiral-out readouts without compromising BOLD sensitivity. The shorter TE provides a reduced TR, improvement in tSNR and minimizes off-resonance effects. We conclude that spiral-in readouts are mostly useful for lower resolutions at UHF, but that segmented spiral-out readouts can play an important role in mesoscopic BOLD fMRI at ultra high fields (> 7T).

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Additional details

Funding

European Commission
AROMA - Accurate, Reliable and Optimized functional MAgnetic resonance imaging at unprecedented field strength for unique exploration of the human brain 885876