INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCE (IJPBS)
Published October 1, 2025 | Version v1
Journal article Open

Alternations of Hemostatic Balance Induced By a Hypercaloric Diet

Authors/Creators

  • 1. 1Nutritional Sciences Laboratory, Department of Food Sciences and Nutrition, Guinean Higher School of Tourism and Hospitality, Conakry, Guinea

Contributors

  • 1. 2Laboratory of Pharmacology and Improved Traditional Medicines, Department of Animal Physiology, Faculty of Science and Technology, University of Abomey-Calavi, BP 526 Cotonou, Republic of Benin 3Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology, University of Abomey-Calavi, Abomey Calavi, Benin

Description

Abstract

The study entitled "Alterations of Hemostatic Balance Induced by a Hypercaloric Diet" aims to assess the impact of a calorie-rich diet on blood coagulation mechanisms. Hemostasis, a physiological process maintaining vascular integrity, can be disrupted by metabolic disorders linked to obesity. To explore this relationship, twenty-four male Wistar rats were divided into two groups : a control group fed a standard diet and a test group subjected to a hypercaloric diet for 30 days. Body weight, Lee index, and adiposity rate confirmed the induction of an obese state in treated animals. Biologically, these rats exhibited hypercoagulability characterized by significant reductions in bleeding time, coagulation time, aPTT, prothrombin time, and thrombin time, a marked increase in platelet count and D-dimer levels, and a paradoxical decrease in fibrinogen levels. These alterations indicate excessive activation of hemostatic mechanisms, likely triggered by chronic inflammation, oxidative stress, and hepatic dysfunction associated with obesity. The results reveal a profound disruption of hemostatic balance due to the hypercaloric diet, highlighting the vascular risks of nutritional excess. This experimental model supports the importance of a preventive nutritional approach to reduce thromboembolic complications related to obesity.

 

Keywords

Obesity, Hypercaloric diet, Hemostasis, Hypercoagulability, Wistar rat.

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References

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