Published October 2, 2025 | Version v1
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The Efficacy of Butylphthalide in Patients with Acute Ischemic Stroke: A Review of Clinical Evidence

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Description

Introduction. Ischemic stroke constitutes one of the principal causes of global
disability and mortality. Certain investigations have demonstrated that
DL-3-n-butylphthalide exerts a significant neuroprotective effect in the context of
cerebral ischemia. The aim of the study is to evaluate the efficacy of butylphthalide
in the treatment of acute ischemic stroke.
Materials and methods. A review of publications was conducted using the
PubMed and ScienceDirect scientific databases. Consideration was given to the
year of publication, with preference accorded to articles from the last decade. The
inclusion criteria excluded non-randomized studies, investigations examining
the effects of butylphthalide in combination with other pharmaceuticals, and research
not specifically focused on patients with acute ischemic stroke.
Results. The selected studies enrolled exclusively Chinese patients, with a total
cohort of 2,622 individuals. Therapeutic efficacy was assessed by monitoring the
dynamics of neurological deficit using the US National Institutes of Health Stroke
Scale and by evaluating the recovery of functional independence in daily living
according to the Barthel Index. The data obtained at various stages of treatment
have been compiled into tables.
Discussion and conclusion. The data from the studies reviewed herein indicate
that butylphthalide is efficacious when administered early to patients
experiencing ischemic stroke. However, definitive confirmation of its clinical
significance necessitates further large-scale, multi-center trials with extended
follow-up periods. These trials must encompass not only Chinese populations
but also diverse ethnic groups.

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2025-09-22

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