Published July 3, 2025 | Version v1
Journal article Open

Electrofisiología del corazón humano: de la bioelectricidad celular a las aplicaciones clínicas

Authors/Creators

  • 1. Universidad Nacional de Chimborazo
  • 2. Escuela Superior Politécnica de Chimborazo

Description

La electrofisiología cardíaca humana ha experimentado una evolución, pasando del estudio de los mecanismos bioeléctricos celulares, como la generación y propagación de potenciales de acción y la función de los canales iónicos, a su aplicación clínica en el diagnóstico y tratamiento de enfermedades cardíacas. El presente estudio tuvo como objetivo realizar un análisis bibliométrico de la producción científica relacionada con este campo, con el fin de identificar su evolución temporal, los actores más influyentes y las principales áreas temáticas abordadas. Para ello, se recuperaron estudios desde la base de datos Scopus mediante una estrategia de búsqueda enfocada en términos clave vinculados a la electrofisiología, la bioelectricidad celular y sus aplicaciones clínicas. Se analizaron un total de 409 publicaciones utilizando el software Bibliometrix, a través de su interfaz Biblioshiny. Los resultados evidenciaron un crecimiento sostenido en la producción científica, con un notable incremento en las últimas dos décadas. Revistas de alto impacto, como Cardiovascular Research y Journal of Cardiovascular Electrophysiology, junto con autores como Dobrev D. y Nattel S., destacaron por su influencia en el campo. Asimismo, Estados Unidos, Alemania y Reino Unido fueron los países con mayor frecuencia de contribuciones, mientras que los términos más recurrentes reflejan el interés sostenido por los mecanismos celulares y su aplicación clínica. Las redes de colaboración revelaron una fuerte interconexión entre instituciones europeas y norteamericanas. En conclusión, este estudio proporciona una visión integral de la evolución, actores clave y tendencias temáticas en electrofisiología cardíaca, ofreciendo un marco útil para orientar futuras investigaciones en el área.

Abstract (English)

Human cardiac electrophysiology has undergone significant evolution, transitioning from the study of cellular bioelectrical mechanisms such as the generation and propagation of action potentials and the function of ion channels to its clinical application in the diagnosis and treatment of heart diseases. The present study aimed to conduct a bibliometric analysis of the scientific output related to this field, in order to identify its temporal evolution, the most influential contributors, and the main thematic areas addressed. To achieve this, studies were retrieved from the Scopus database using a search strategy focused on key terms related to electrophysiology, cellular bioelectricity, and their clinical applications. A total of 409 publications were analyzed using the Bibliometrix software through its Biblioshiny interface. The results revealed a sustained growth in scientific output, with a notable increase over the past two decades. High-impact journals, such as Cardiovascular Research and Journal of Cardiovascular Electrophysiology, along with authors like Dobrev D. and Nattel S., stood out for their influence in the field. Similarly, the United States, Germany, and the United Kingdom were the countries with the highest frequency of contributions, while the most frequently used terms reflected ongoing interest in cellular mechanisms and their clinical application. Collaboration networks revealed strong interconnections among European and North American institutions. In conclusion, this study provides a comprehensive overview of the evolution, key contributors, and thematic trends in cardiac electrophysiology, offering a useful framework to guide future research in the field.

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Additional details

Additional titles

Translated title (English)
Electrophysiology of the human heart: from cellular bioelectricity to clinical applications

Identifiers

ISSN
2960-8317
DOI
10.61347/ei.v4i2.142

Dates

Submitted
2025-05-19
Recibido
Accepted
2025-06-18
Aceptado

References

  • Abbas, A., Jusoh, A., Mas'od, A., Alsharif, A., & Ali, J. (2022). Bibliometrix analysis of information sharing in social media. Cogent Business & Management, 9(1), 2016556. https://doi.org/10.1080/23311975.2021.2016556
  • Ampese, L. C., Sganzerla, W. G., Ziero, H., Mudhoo, A., Martins, G., & Forster-Carneiro, T. (2022). Research progress, trends, and updates on anaerobic digestion technology: A bibliometric analysis. Journal of Cleaner Production, 331, 130004. https://doi.org/10.1016/j.jclepro.2021.130004
  • Aria, M., & Cuccurullo, C. (2017). Bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of Informetrics, 11(4), 959-975. https://doi.org/10.1016/j.joi.2017.08.007
  • Bucelli, M., Zingaro, A., Africa, P., Fumagalli, I., Dede', L., & Quarteroni, A. (2023). A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart. International Journal for Numerical Methods in Biomedical Engineering, 39(3), e3678. https://doi.org/10.1002/cnm.3678
  • Campra, M., Riva, P., Oricchio, G., & Brescia, V. (2022). Bibliometrix analysis of medical tourism. Health Services Management Research, 35(3), 172-188. https://doi.org/10.1177/09514848211011738
  • Donthu, N., Kumar, S., Mukherjee, D., Pandey, N., & Lim, W. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of Business Research, 133, 285-296. https://doi.org/10.1016/j.jbusres.2021.04.070
  • Ejaz, H., Zeeshan, H., Ahmad, F., Bukhari, S., Anwar, N., Alanazi, A., Sadiq, A., Junaid, K., Atif, M., Abosalif, K., Iqbal, A., Hamza, M., & Younas, S. (2022). Bibliometric Analysis of Publications on the Omicron Variant from 2020 to 2022 in the Scopus Database Using R and VOSviewer. International Journal of Environmental Research and Public Health, 19(19), 12407. https://doi.org/10.3390/ijerph191912407
  • Guleria, D., & Kaur, G. (2021). Bibliometric analysis of ecopreneurship using VOSviewer and RStudio Bibliometrix, 1989–2019. Library Hi Tech, 39(4), 1001-1024. https://doi.org/10.1108/LHT-09-2020-0218
  • Khan, A., Goodell, J., Hassan, M., & Paltrinieri, A. (2022). A bibliometric review of finance bibliometric papers. Finance Research Letters, 47, 102520. https://doi.org/10.1016/j.frl.2021.102520
  • Li, L., & Xie, B. (2025). Pulsed field ablation for atrial fibrillation: A comprehensive bibliometric analysis of research trends and emerging Frontiers. Frontiers in Cardiovascular Medicine, 12. https://doi.org/10.3389/fcvm.2025.1513942
  • Liang, M., Zhang, J., Li, G., & Wang, P. (2024). Global research progress on radiofrequency ablation in cardiology: A bibliometric analysis (2004–2023). Medicine, 103(23), e38498. https://doi.org/10.1097/MD.0000000000038498
  • Mishra, M., Sudarsan, D., Santos, C., Mishra, S., Kar, D., Baral, K., & Pattnaik, N. (2021). An overview of research on natural resources and indigenous communities: A bibliometric analysis based on Scopus database (1979–2020). Environmental Monitoring and Assessment, 193(2), 59. https://doi.org/10.1007/s10661-020-08793-2
  • Piccini, J., Russo, A., Sharma, P., Kron, J., Tzou, W., Sauer, W., Park, D., Birgersdotter-Green, U., Frankel, D., Healey, J., Hummel, J., Koruth, J., Linz, D., Mittal, S., Nair, D., Nattel, S., Noseworthy, P., Steinberg, B., Trayanova, N., … Wang, P. (2022). Advances in Cardiac Electrophysiology. Circulation: Arrhythmia and Electrophysiology, 15(12), e009911. https://doi.org/10.1161/CIRCEP.121.009911
  • Plank, G., Loewe, A., Neic, A., Augustin, C., Huang, Y.-L., Gsell, M., Karabelas, E., Nothstein, M., Prassl, A., Sánchez, J., Seemann, G., & Vigmond, E. (2021). The openCARP simulation environment for cardiac electrophysiology. Computer Methods and Programs in Biomedicine, 208, 106223. https://doi.org/10.1016/j.cmpb.2021.106223
  • Pranckutė, R. (2021). Web of Science (WoS) and Scopus: The Titans of Bibliographic Information in Today's Academic World. Publications, 9(1), 12. https://doi.org/10.3390/publications9010012
  • Ripplinger, C., Glukhov, A., Kay, M., Boukens, B., Chiamvimonvat, N., Delisle, B., Fabritz, L., Hund, T., Knollmann, B., Li, N., Murray, K., Poelzing, S., Quinn, T., Remme, C., Rentschler, S., Rose, R., & Posnack, N. (2022). Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals. American Journal of Physiology-Heart and Circulatory Physiology, 323(6), H1137-H1166. https://doi.org/10.1152/ajpheart.00439.2022
  • Trayanova, N., Popescu, D., & Shade, J. (2021). Machine Learning in Arrhythmia and Electrophysiology. Circulation Research, 128(4), 544-566. https://doi.org/10.1161/CIRCRESAHA.120.317872
  • Ullah, R., Asghar, I., & Griffiths, M. (2023). An Integrated Methodology for Bibliometric Analysis: A Case Study of Internet of Things in Healthcare Applications. Sensors, 23(1), 67. https://doi.org/10.3390/s23010067
  • Yadav, M., & Banerji, P. (2023). A bibliometric analysis of digital financial literacy. American Journal of Business, 38(3), 91-111. https://doi.org/10.1108/AJB-11-2022-0186
  • Zhang, G., & Levin, M. (2025). Bioelectricity is a universal multifaced signaling cue in living organisms. Molecular Biology of the Cell, 36(2), 1-8. https://doi.org/10.1091/mbc.E23-08-0312
  • Zhang, L., Ling, J., & Lin, M. (2022). Artificial intelligence in renewable energy: A comprehensive bibliometric analysis. Energy Reports, 8, 14072-14088. https://doi.org/10.1016/j.egyr.2022.10.347
  • Zhu, X., Lv, M., Cheng, T., Zhou, Y., Yuan, G., Chu, Y., Luan, Y., Song, Q., & Hu, Y. (2024). Bibliometric analysis of atrial fibrillation and ion channels. Heart Rhythm, 21(7), 1161-1169. https://doi.org/10.1016/j.hrthm.2024.01.032