Published September 21, 2025 | Version v1
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EFFECTS OF GARCINIA KOLA ETHANOLIC EXTRACTS ON SEX HORMORNES IN STARVATION-INDUCED STRESS MALE WISTAR RATS MODEL

Authors/Creators

  • 1. Department of Human Physiology School of Basic Medical Sciences, College of Health Sciences University of Benin, Benin CityEdo State, Nigeria.
  • 2. Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences University of PortHarcourt, Rivers State Nigeria.
  • 3. Department of Human Physiology, Faculty of Basic Medical Sciences College of Health Sciences Niger Delta University Ammasona Bayelsa State, Nigeria.
  • 4. Department of Chemistry, Faculty of Science University of Lagos, Lagos State, Nigeria.

Description

Aim/Objective: This study investigated the Effects of Starvation-Induced Stress and ethanolic extracts of Garcinia kola on sex hormones in male wistar rat’s models. Materials/Methods: forty male wistar rats, weighing between 120-200g were purchased and acclimatized for a period of 14 days. They were divided into 4 Groups; Groups A (control) was fed with standard diets and water only with no starvation while groups B, C and D were each treated with 1ml of G. kola extract at different concentration. The experiment for starvation induced stress lasted for 42 days while that for the ethanolic extract of G. kola took 28 days. Group B were fed with 15 hours SD with 9 hours of starvation and treated at 25mg/kg. Group C were fed with 6 hours SD with 18 hours of starvation and treated at 50mg/kg while Group D were fed with 12 hours and treated at 100mg/kg ethanolic extract of G-Kola respectively. The Layman and Tiet method was used to determine the various sex hormones. Results: The change in body weights was (control = 58.50g, test groups=40.50g, 56.50g) while those administered ethanolic extracts of G. kola at 25mg/kg(1.55ng/ml), 50mg/kg (0.98ng/ml) and 100mg/kg (0.96ng/ml) was observed to progressively decrease LH serum level compared with the control. Similar decrease was also observed in FSH and testosterone as well when compared with the control group respectively while FSH, LH and Testosterone remain unchanged (p>0.05) in starved rats administered SD and water only. Conclusion: The results of this study indicated a remarkable decrease in male reproductive sex hormones in starvation induced stressed male wistar rats administered prolonged G. kola ethanolic extracts.

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