Novel mouse glioma model: cell-type and region specific activation of oncogenes using lentiviral vectors

Glioblastomas (GBMs) are highly malignant because of their high mitotic activity and prominent invasive characteristic. Animal models are very essential in order to understand the biology of the disease and to find and validate new therapies. Various animal models for GBMs have been reported so far, however each model has strengths and drawbacks.