Network Pharmacology and Molecular Docking of Mucuna Pruriens in Treatment of Depression

Mucuna pruriens, a medicinal plant rich in L-DOPA and bioactive phytochemicals, exhibits potential antidepressant effects through modulation of neurotransmitter systems. This study integrates network pharmacology and molecular docking to elucidate its therapeutic mechanisms against depression. Bioactive compounds were screened for pharmacokinetic properties, and their targets were identified using public databases. Protein–protein interaction and pathway enrichment analyses revealed involvement in dopaminergic, serotonergic, and neurotrophic signaling pathways. Molecular docking confirmed strong binding affinities between key phytochemicals and depression-related targets such as MAO-A, SERT, and BDNF receptors. Findings provide a systems-level understanding, supporting Mucuna pruriens as a promising natural antidepressant.