CASE REPORT MANAGEMENT OF SYMBLEPHARONASSOCIATED WITH DRY EYE SECONDARY TO GRAFT-VERSUS-HOST-DISEASE (GVHD)

Ocular Graft-Versus-Host Disease (GVHD) is a serious complication following bone marrow transplantation,often marked by chronic inflammation and severe tear dysfunction.Clinical treatment is often insufficient, requiring surgical intervention. We report a case of a 27-year-old male with ocular GVHD refractory to optimized clinical management. Clinical findings included ptosis,symblepharon,corneal neovascularization,and a Schirmer test of 0 mm. The patient underwent symblepharon excision and fornix reconstruction using oral mucosa graft, with further planning for salivary gland transplantation.After 40 days,partial improvement was observed, with intact graft and no superior epithelial defect. This case highlights the importance of a multidisciplinary, personalized approach in the management of severe ocular GVHD.